Université de Fribourg

Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes

Vassella, Erik ; Probst, Matthias ; Schneider, André ; Studer, Erwin ; Kunz Renggli, Christina ; Roditi, Isabel

In: Molecular Biology of the Cell, 2004, vol. 15, p. 3986-3993

In cycling between the mammalian host and the tsetse fly vector, trypanosomes undergo major changes in energy metabolism and surface coat composition. Early procyclic (insect) forms in the tsetse fly midgut are coated by glycoproteins known as EP and GPEET procyclins. EP expression continues in late procyclic forms, whereas GPEET is down-regulated. In culture, expression of GPEET is modulated by...

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1 Vassella, E.