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An MVA vector expressing HIV-1 envelope under the control of a potent vaccinia virus promoter as a promising strategy in HIV/AIDS vaccine design

Pérez, Patricia ; Marín, María Q. ; Lázaro-Frías, Adrián ; Sorzano, Carlos Óscar S. ; Di Pilato, Mauro ; Gómez, Carmen E. ; Esteban, Mariano ; García-Arriaza, Juan

In: Vaccines, 2019, vol. 7, no. 4, p. 208

Highly attenuated poxviral vectors, such as modified vaccinia virus ankara (MVA), are promising vaccine candidates against several infectious diseases. One of the approaches developed to enhance the immunogenicity of poxvirus vectors is increasing the promoter strength and accelerating during infection production levels of heterologous antigens. Here, we have generated and characterized the ...