In: Biophysical Chemistry, 2004, vol. 112, p. 45-57
Kosmotropic cosolvents added to an aqueous solution promote the aggregation of hydrophobic solute particles, while chaotropic cosolvents act to destabilise such aggregates. We discuss the mechanism for these phenomena within an adapted version of the two-state Muller–Lee–Graziano model for water, which provides a complete description of the ternary water/cosolvent/solute system for small...
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