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    Université de Fribourg

    Negative association between left prefrontal GABA concentration and BDNF serum concentration in young adults

    Müller, Sabrina Theresia ; Buchmann, Andreas ; Haynes, Melanie ; Ghisleni, Carmen ; Ritter, Christopher ; Tuura, Ruth ; Hasler, Gregor

    In: Heliyon, 2020, vol. 6, no. 5, p. e04025

    The brain's major inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and the brain-derived neurotrophic factor (BDNF) play important roles in several stress- related disorders. Magnetic resonance spectroscopy (MRS) allows for non-invasive quantification of GABA concentration in the brain. We investigated the relationship between GABA concentration in the left dorsolateral prefrontal...

    Université de Fribourg

    Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy

    Hasler, Gregor ; Buchmann, Andreas ; Haynes, Melanie ; Müller, Sabrina Theresia ; Ghisleni, Carmen ; Brechbühl, Sarela ; Tuura, Ruth

    In: Translational Psychiatry, 2019, vol. 9, no. 1, p. 170

    There is growing evidence for GABA and glutamate–glutamine dysfunction in the pathogenesis of mood and anxiety disorders. It is important to study this pathology in the early phases of the illness in order to develop new approaches to secondary prevention. New magnetic resonance spectroscopy (MRS) measures allow determining glutamine, the principal metabolite of synaptic glutamate that is...

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