Université de Fribourg

EEF1A1 deacetylation enables transcriptional activation of remyelination

Duman, Mert ; Vaquié, Adrien ; Nocera, Gianluigi ; Heller, Manfred ; Stumpe, Michael ; Sankar, Devanarayanan Siva ; Dengjel, Jörn ; Meijer, Dies ; Yamaguchi, Teppei ; Matthias, Patrick ; Zeis, Thomas ; Schaeren-Wiemers, Nicole ; Hayoz, Antoinette ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2020, vol. 11, no. 1, p. 3420

Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1...

Université de Fribourg

Injured axons instruct schwann cells to build constricting actin spheres to accelerate axonal disintegration

Vaquié, Adrien ; Sauvain, Alizée ; Duman, Mert ; Nocera, Gianluigi ; Egger, Boris ; Meyenhofer, Felix ; Falquet, Laurent ; Bartesaghi, Luca ; Chrast, Roman ; Lamy, Christophe Maurice ; Bang, Seokyoung ; Lee, Seung-Ryeol ; Jeon, Noo Li ; Ruff, Sophie ; Jacob, Claire

In: Cell Reports, 2019, vol. 27, no. 11, p. 3152-3166.e7

After a peripheral nerve lesion, distal ends of injured axons disintegrate into small fragments that are subsequently cleared by Schwann cells and later by macrophages. Axonal debris clearing is an early step of the repair process that facilitates regeneration. We show here that Schwann cells promote distal cut axon disintegration for timely clearing. By combining cell-based and in vivo...

Université de Fribourg

Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

Brügger, Valérie ; Duman, Mert ; Bochud, Maëlle ; Münger, Emmanuelle ; Heller, Manfred ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2017, vol. 8, p. 14272

The peripheral nervous system (PNS) regenerates after injury. However, regeneration is often compromised in the case of large lesions, and the speed of axon reconnection to their target is critical for successful functional recovery. After injury, mature Schwann cells (SCs) convert into repair cells that foster axonal regrowth, and redifferentiate to rebuild myelin. These processes require...