In: Eurosurveillance, 2017, vol. 22, no. 49, p. 17-00048
OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204- positive enterobacterial isolates (n = 29) recovered in France between...
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In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 1, p. 98-102
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In: Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 3, p. 623-627
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In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 11, p. 3014-3022
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In: Eurosurveillance, 2017, vol. 22, no. 6, p. -
In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance mechanism to carbapenems and compared with results obtained during 2012 and 2013.The overall number of enterobacterial isolates with decreased...
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In: Antimicrobial Agents and Chemotherapy, 2017, vol. 61, no. 3, p. e02413-16
The metallo-β-lactamase NDM-1 is among the most worrisome resistance determinants and is spreading worldwide among Gram-negative bacilli. A bleomycin resistance gene, bleMBL, downstream of the blaNDM-1 gene has been associated with resistance almost systematically. Here, we characterized the corresponding protein, BRPMBL, conferring resistance to bleomycin,...
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In: Eurosurveillance, 2016, vol. 21, no. 37, p. -
From January 2014 to December 2014, 972 consecutive non-replicate carbapenemase-producing Enterobacteriaceae isolates from colonised or infected patients were collected at the Associated French National Reference Centre as part of the French national survey on antimicrobial resistance. It included 577 Klebsiella spp. (59%), 236 Escherichia coli (24%), 108 Enterobacter spp. (11%), 50...
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In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 1, p. 98-102
To decipher the mechanisms and their associated genetic determinants responsible for β-lactam resistance in a Proteus mirabilis clinical isolate.Methods: The entire genetic structure surrounding the β-lactam resistance genes was characterized by PCR, gene walking and DNA sequencing.Results: Genes encoding the carbapenemase NDM-1 and the ESBL VEB-6 were located in a 38.5 kb MDR structure,...
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In: Antimicrobial Agents and Chemotherapy, 2016, vol. 59, no. 12, p. 7420–7425
An Enterobacter cloacae isolate was recovered from a rectal swab from a patient hospitalized in France with previous travel to Switzerland. It was resistant to penicillins, narrow- and broad-spectrum cephalosporins, aztreonam, and carbapenems but remained susceptible to expanded-spectrum cephalosporins. Whereas PCR-based identification of the most common carbapenemase genes failed, the...
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In: International Journal of Antimicrobial Agents, 2016, vol. 47, no. 1, p. 102–103
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