Université de Fribourg

Optical and theoretical study of strand recognition by nucleic acid probes

Domljanovic, Ivana ; Taskova, Maria ; Miranda, Pâmella ; Weber, Gerald ; Astakhova, Kira

In: Communications Chemistry, 2020, vol. 3, no. 1, p. 111

Detection of nucleic acids is crucial to the study of their basic properties and consequently to applying this knowledge to the determination of pathologies such as cancer. In this work, our goal is to determine new trends for creating diagnostic tools for cancer driver mutations. Herein, we study a library of natural and modified oligonucleotide duplexes by a combination of optical and...

Université de Fribourg

DNA origami as emerging technology for the engineering of fluorescent and plasmonic-based biosensors

Loretan, Morgane ; Domljanovic, Ivana ; Lakatos, Mathias ; Rüegg, Curzio ; Acuna, Guillermo P.

In: Materials, 2020, vol. 13, no. 9, p. 2185

DNA nanotechnology is a powerful and promising tool for the development of nanoscale devices for numerous and diverse applications. One of the greatest potential fields of application for DNA nanotechnology is in biomedicine, in particular biosensing. Thanks to the control over their size, shape, and fabrication, DNA origami represents a unique opportunity to assemble dynamic and complex...