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Bis-retinoid A2E induces an increase of basic fibroblast growth factor via inhibition of extracellular signal-regulated kinases 1/2 pathway in retinal pigment epithelium cells and facilitates phagocytosis

Balmer, Delphine ; Bapst-Wicht, Linda ; Pyakurel, Aswin ; Emery, Martine ; Nanchen, Natacha ; Bochet, Christian G. ; Roduit, Raphael

In: Frontiers in Aging Neuroscience, 2017, vol. 9, p. -

Age-related macular degeneration (ARMD) is the leading cause of vision loss in developed countries. Hallmarks of the disease are well known; indeed, this pathology is characterized by lipofuscin accumulation, is principally composed of lipid-containing residues of lysosomal digestion. The N-retinyl-N-retinylidene ethanolamine (A2E) retinoid which is thought to be a cytotoxic component for RPE...