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    Université de Lausanne

    Regulation of the expression of Nav1.5, the cardiac voltage-gated sodium channel

    Gavillet, Bruno ; Abriel, Hugues (Dir.) ; Rossier, Bernard C. (Codir.)

    Thèse de doctorat : Université de Lausanne, 2006.

    The cardiac sodium channel Nav1.5 plays a key role in cardiac excitability and conduction. Its importance for normal cardiac function has been highlighted by descriptions of numerous mutations of SCN5A (the gene encoding Nav1.5), causing cardiac arrhythmias which can lead to sudden cardiac death. The general aim of my PhD research project has been to investigate the regulation of Nav1.5 along two...