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Immunological consequences of intragenus conservation of Mycobacterium tuberculosis T-cell epitopes

Lindestam Arlehamn, Cecilia S. ; Paul, Sinu ; Mele, Federico ; Huang, Charlie ; Greenbaum, Jason A. ; Vita, Randi ; Sidney, John ; Peters, Bjoern ; Sallusto, Federica ; Sette, Alessandro

In: Proceedings of the national academy of sciences of the United States of America, 2015, vol. 112, no. 2, p. E147-E155

A previous unbiased genome-wide analysis of CD4 Mycobacterium tuberculosis (MTB) recognition using peripheral blood mononuclear cells from individuals with latent MTB infection (LTBI) or nonexposed healthy controls (HCs) revealed that certain MTB sequences were unexpectedly recognized by HCs. In the present study, it was found that, based on their pattern of reactivity, epitopes could be...