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Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells

Gonçalves Silva, Isabel ; Gibbs, Bernhard F. ; Bardelli, Marco ; Varani, Luca ; Sumbayev, Vadim V.

In: Oncotarget, 2015, vol. 6, no. 32, p. 33823-33833

The T cell immunoglobulin and mucin domain 3 (Tim-3) is a plasma membrane-associated receptor which is involved in a variety of biological responses in human immune cells. It is highly expressed in most acute myeloid leukaemia (AML) cells and therefore may serve as a possible target for AML therapy. However, its biochemical activities in primary human AML cells remain unclear. We therefore...