In: The journal of experimental medicine, 2013, vol. 210, no. 3, p. 445-455
Antibodies targeting citrullinated proteins (ACPAs [anticitrullinated protein antibodies]) are commonly found in patients with rheumatoid arthritis (RA), strongly associate with distinct HLA-DR alleles, and predict a more aggressive disease course as compared with seronegative patients. Still, many features of these antibodies, including their site of production and the extent of MHC class...
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In: Theory of Computing Systems, 2005, vol. 38, no. 3, p. 279-292
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Thèse de doctorat : Università della Svizzera italiana, 2017 ; 2017INFO002.
Causal loops are loops in cause-effect chains: An effect can be the cause of that effect's cause. We show that causal loops can be unproblematic, and explore them from different points of view. This thesis is motivated by quantum theory, general relativity, and quantum gravity. By accepting all of quantum theory one can ask whether the possibility to take superpositions extends to causal...
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In: The EMBO Journal, 2019, vol. 38, no. 7, p. e101005
DNA end resection initiates DNA break repair by homologous recombination. MRE11-RAD50-NBS1 and phosphorylated CtIP perform the first resection step by MRE11-catalyzed endonucleolytic DNA cleavage. Human NBS1, more than its Xrs2 homologue from Saccharomyces cerevisiae, is crucial for this process, highlighting complex mechanisms that regulate the MRE11 nuclease in high eukaryotes. Using a...
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In: Journal of computational and applied mathematics, 2019, vol. 350, p. 114-129
Barycentric coordinates provide a convenient way to represent a point inside a triangle as a convex combination of the triangle’s vertices and to linearly interpolate data given at these vertices. Due to their favourable properties, they are commonly applied in geometric modelling, finite element methods, computer graphics, and many other fields. In some of these applications, it is desirable...
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Thèse de doctorat : Università della Svizzera italiana, 2017 ; 2017INFO004.
Different coordinate systems allow to uniquely determine the position of a geometric element in space. In this dissertation, we consider a coordinate system that lets us determine the position of a two-dimensional point in the plane with respect to an arbitrary simple polygon. Coordinates of this system are called generalized barycentric coordinates in 2D and are widely used in computer...
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In: International journal of environmental research and public health, 2021, vol. 18, no. 5, p. 15 p
Background: The pervasiveness of smartphones has raised concerns about an increase in the prevalence of problematic smartphone use (PSU), which depends on a set of psychological and behavioral risk factors. Previous research has yielded mixed results on factors predicting PSU, including social anxiety and trust. In particular, the role of trust remained largely unexplored. In the present study,...
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Effective parallelization of fine-grained tasks, such as in dynamic program analysis, is challenging because thread communication overheads may outweigh the benefits of parallelism. In this paper, we address this issue with deferred methods, a novel Java framework that aggregates invocations of analysis methods in thread-local buffers and processes them altogether when a buffer is full. The...
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Thèse de doctorat : Università della Svizzera italiana, 2011 ; 2011INFO006.
Coarse Grained Reconfigurable Arrays have emerged, in recent years, as promising candidates to realize efficient reconfigurable platforms. CGRAs feature high computational density, flexible routing interconnect and rapid reconfiguration, characteristics that make them well-suited to speed up execution of computational kernels. A number of designs embodying the CGRA concept have been proposed...
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The purpose of this study is to estimate a multivariate variable cost function in order to analyze the cost structure of a sample of Italian water distribution companies. The empirical results of this study could be used by the Italian Regulation Authority of this sector for two purposes: first, to improve the actual tariff regulation process, based on a benchmarking of variable costs, and...
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