In: Argumentation, 2014, vol. 28, no. 1, p. 19-37
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In: Sustainability Science, 2014, vol. 9, no. 1, p. 89-102
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In: The Journal of clinical investigation, 2010, vol. 120, no. 5, p. 1663-1673
The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1–H16). The neutralizing antibody response to influenza virus is thought to be specific for a few antigenically related isolates within a given subtype. However, while heterosubtypic...
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In: Scientific reports, 2018, vol. 8, no. 1, p. 11112
Based on the development of new algorithms and growth of sequence databases, it has recently become possible to build robust higher-order sequence models based on sets of aligned protein sequences. Such models have proven useful in de novo structure prediction, where the sequence models are used to find pairs of residues that co-vary during evolution, and hence are likely to be in spatial...
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In: Plos one, 2010, vol. 5, no. 4, p. e10159
Background: Migration of mammalian cells is a complex cell type and environment specific process. Migrating hematopoietic cells assume a rapid amoeboid like movement when exposed to gradients of chemoattractants. The underlying signaling mechanisms remain controversial with respect to localization and distribution of chemotactic receptors within the plasma membrane and the role of PI 3-kinase...
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In: Plos one, 2010, vol. 5, no. 2, p. e9175
Background: CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest a signaling activity in mammalian cells and zebrafish embryos, while others indicate a decoy...
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In: Plos one, 2010, vol. 5, no. 1, p. e8805
Background The isolation of human monoclonal antibodies (mAbs) that neutralize a broad spectrum of primary HIV-1 isolates and the characterization of the human neutralizing antibody B cell response to HIV-1 infection are important goals that are central to the design of an effective antibody-based vaccine. Methods and Findings We immortalized IgG+ memory B cells from individuals infected with...
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In: Quaderni dell’Istituto di Storia dell’Architettura, 2017, no. n.s. 66, p. 41-58
Alla luce della più recente letteratura, attenta alla comprensione delle specificità operative di Domenico Fontana, la presente ricerca ha inteso apportare un contributo sul cantiere dell’ospedale dei Poveri Mendicanti (opera realizzata su commissione di Sisto V a conclusione di via Giulia, nei pressi di ponte Sisto, tra l’ottobre 1586 e il gennaio 1589) attraverso l’analisi del libro...
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In: Quaderni dell’Istituto di Storia dell’Architettura, 2017, no. n.s. 66, p. 59-78
Durante il pontificato di Sisto V (1585-1590) la basilica di San Petronio fu oggetto dell’attenzione papale che si concentrò sulla realizzazione delle volte della navata centrale. Ma l’intervento sistino, che vide il coinvolgimento di Giacomo Della Porta e Domenico Fontana, diede vita ad un’accesa controversia che, travalicando la problematica contingente sull’altezza più opportuna...
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In: Pratiche architettoniche a confronto nei cantieri italiani della seconda metà del Cinquecento, 2019, p. [VII]-XXV
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