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Università della Svizzera italiana

Modelling protein-protein interactions to elucidate molecular mechanisms behind neurodegenerative diseases

Grasso, Gianvito ; Krause, Rolf (Dir.) ; Danani, Andrea (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO017.

The worldwide significant increase in life expectancy has recently drawn the attention of the scientific community to neurodegenerative pathologies of the elderly population. These neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading to intracellular inclusions or extracellular aggregates in specific brain areas. A feasible strategy to prevent...

Università della Svizzera italiana

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

Markle, Janet G. ; Martínez-Barricarte, Rubén ; Ma, Cindy S. ; Deenick, Elissa K. ; Ramírez-Alejo, Noé ; Mele, Federico ; Latorre, Daniela ; Mahdaviani, Seyed Alireza ; Aytekin, Caner ; Mansouri, Davood ; Bryant, Vanessa L. ; Jabot-Hanin, Fabienne ; Deswarte, Caroline ; Nieto-Patlán, Alejandro ; Surace, Laura ; Kerner, Gaspard ; Itan, Yuval ; Jovic, Sandra ; Avery, Danielle T. ; Wong, Natalie ; Rao, Geetha ; Patin, Etienne ; Okada, Satoshi ; Bigio, Benedetta ; Boisson, Bertrand ; Rapaport, Franck ; Seeleuthner, Yoann ; Schmidt, Monika ; Ikinciogullari, Aydan ; Dogu, Figen ; Tanir, Gonul ; Tabarsi, Payam ; Bloursaz, Mohammed Reza ; Joseph, Julia K. ; Heer, Avneet ; Kong, Xiao-Fei ; Migaud, Mélanie ; Lazarov, Tomi ; Geissmann, Frédéric ; Fleckenstein, Bernhard ; Lindestam Arlehamn, Cecilia ; Sette, Alessandro ; Puel, Anne ; Emile, Jean-François ; Vosse, Esther van de ; Quintana-Murci, Lluis ; Di Santo, James P. ; Abel, Laurent ; Boisson-Dupuis, Stéphanie ; Bustamante, Jacinta ; Tangye, Stuart G. ; Sallusto, Federica ; Casanova, Jean-Laurent

In: Science Immunology, 2018, vol. 3, no. 30, p. eaau6759

Hundreds of patients with autosomal recessive, complete IL-12p40 or IL-12Rß1 deficiency have been diagnosed over the last 20 years. They typically suffer from invasive mycobacteriosis and, occasionally, from mucocutaneous candidiasis. Susceptibility to these infections is thought to be due to impairments of IL-12–dependent IFN-? immunity and IL-23–dependent IL-17A/IL-17F immunity,...

Università della Svizzera italiana

Three essays in economics of catastrophes

Slerca, Edoardo ; Jametti, Mario (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018ECO013.

Many events can have a catastrophic effect on an economic environment, such as natural disasters, wars, migrations, pandemic diseases, etc. This thesis focuses on three of them: catastrophic agglomeration of firms as a response to tax differentials, immigration phenomena described as catastrophic by the natives and catastrophic earthquakes with destructive consequences for both physical and...

Università della Svizzera italiana

Exposing concurrency failures : a comprehensive survey of the state of the art and a novel approach to reproduce field failures

Bianchi, Francesco Adalberto ; Pezzè, Mauro (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO015.

With the rapid advance of multi-core and distributed architectures, concurrent systems are becoming more and more popular. Concurrent systems are extremely hard to develop and validate, as their overall behavior depends on the non-deterministic interleaving of the execution flows that comprise the system. Wrong and unexpected interleavings may lead to concurrency faults that are extremely...

Università della Svizzera italiana

Integrating anti-money laundering compliance duties into the banking culture

Sandulescu, Mihaela ; Barone Adesi, Giovanni (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2016 ; 2016ECO011.

This thesis sets out to investigate whether the anti-money laundering (AML) compliance duties have been integrated into the banking culture. The first two chapters briefly present the Swiss AML framework and relevant numbers. Using survey data from 52 respondents, Chapter 3 presents evidence on how banks coped with compliance requests, starting from the internal due diligence and reporting...

Università della Svizzera italiana

Tracking public opinion on social media

Giachanou, Anastasia ; Crestani, Fabio (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO016.

The increasing popularity of social media has changed the web from a static repository of information into a dynamic forum with continuously changing information. Social media platforms has given the capability to people expressing and sharing their thoughts and opinions on the web in a very simple way. The so-called User Generated Content is a good source of users opinion and mining it can be...

Università della Svizzera italiana

Strategic M&A announcement timing, information asymmetry and behavioral biases

Filipovic, Zoran ; Degeorge, François (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018ECO012.

Mergers and acquisitions (M&As) are among the largest and most important corporate events. Companies acquire other companies for a variety of reasons. The most quoted one is without any doubt the potential additional value from combining two firms, better known as synergy, while the most obscure and the most controversial one is probably the elimination of future competition. No matter what...

Università della Svizzera italiana

Reification as the key to augmenting software development : an object is worth a thousand words

Dal Sasso, Tommaso ; Lanza, Michele (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO014.

Software development has become more and more pervasive, with influence in almost every human activity. To be able to fit in so many different scenarios and constantly implement new features, software developers adopted methodologies with tight development cycles, sometimes with more than one release per day. With the constant growth of modern software projects and the consequent expansion...

Università della Svizzera italiana

Options trading strategies and equity risk premia

Tedeschini, Davide ; Schneider, Paul (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018ECO010.

This doctoral thesis examines, from both a theoretical and an empirical perspective, different aspects of the equity derivative markets, such as the appropriate evaluation of equity risk premia and the development of trading strategies based on options. In the first chapter, entitled “Approximate arbitrage with limit orders”, I introduce an almost riskless trading scheme involving two...

Università della Svizzera italiana

Designing dialogue : argumentation as conflict management in social interaction

Greco, Sara

In: Revue Tranel, 2018, vol. 68, p. 7-15

The escalation of disagreement into overt conflict in social interaction can be avoided, if disagreement is managed through argumentative dialogue. This paper explores the characteristics of argumentative dialogue and presents the role of third parties who design spaces for others' dialogue. After discussing the prototypical example of dispute mediators, this contribution considers other...