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A novel prostate cell type-specific gene signature to interrogate prostate tumor differentiation status and monitor therapeutic response (running title: Phenotypic classification of prostate tumors)

Mapelli, Sarah N. ; Albino, Domenico ; Mello-Grand, Maurizia ; Shinde, Dheeraj ; Scimeca, Manuel ; Bonfiglio, Rita ; Bonanno, Elena ; Chiorino, Giovanna ; Garcia-Escudero, Ramon ; Catapano, Carlo V. ; Carbone, Giuseppina M.

In: Cancers, 2020, vol. 12, no. 1, p. 23 p

In this study, we extracted prostate cell-specific gene sets (metagenes) to define the epithelial differentiation status of prostate cancers and, using a deconvolution-based strategy, interrogated thousands of primary and metastatic tumors in public gene profiling datasets. We identified a subgroup of primary prostate tumors with low luminal epithelial enrichment (LumElow). LumElow tumors were...

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Revandkar, Ajinkya ; Perciato, Maria Luna ; Toso, Alberto ; Alajati, Abdullah ; Chen, Jingjing ; Gerber, Hermeto ; Dimitrov, Mitko ; Rinaldi, Andrea ; Delaleu, Nicolas ; Pasquini, Emiliano ; D’Antuono, Rocco ; Pinton, Sandra ; Losa, Marco ; Gnetti, Letizia ; Arribas, Alberto ; Fraering, Patrick ; Bertoni, Francesco ; Nepveu, Alain ; Andrea Alimonti

In: Nature communications, 2016, vol. 7, p. 13719

Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive. Moreover, preclinical evidence of the therapeutic efficacy of NOTCH inhibitors in prostate cancer is lacking. Here, we provide evidence that PTEN loss in prostate tumours ...

Target Motion Variability and On-Line Positioning Accuracy during External-Beam Radiation Therapy of Prostate Cancer with an Endorectal Balloon Device = Organmobilität und Lokalisationsbestimmung der Prostata unter Einsatz eines endorektalen Ballons bei der Radiotherapie des Prostatakarzinoms

El-Bassiouni, Mazen ; Davis, J. ; El-Attar, Inas ; Studer, Gabriela ; Lütolf, Urs ; Ciernik, I.

In: Strahlentherapie und Onkologie, 2006, vol. 182, no. 9, p. 531-536