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Inferring the age difference in HIV transmission pairs by applying phylogenetic methods on the HIV transmission network of the Swiss HIV Cohort Study

Kusejko, Katharina ; Kadelka, Claus ; Marzel, Alex ; Battegay, Manuel ; Bernasconi, Enos ; Calmy, Alexandra ; Cavassini, Matthias ; Hoffmann, Matthias ; Böni, Jürg ; Yerly, Sabine ; Klimkait, Thomas ; Perreau, Matthieu ; Rauch, Andri ; Günthard, Huldrych F. ; Kouyos, Roger D. ; Scherrer, Alexandra ; Wild, Susanne ; Perraudin, Danièle ; Minichiello, Mirjam ; Anagnostopoulos, A. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Braun, D L. ; Bucher, H C. ; Calmy, A. ; Cavassini, M. ; Ciuffi, A. ; Dollenmaier, G. ; Egger, M. ; Elzi, L. ; Fehr, J. ; Fellay, J. ; Furrer, H. ; Fux, C A. ; Günthard, H F. ; Haerry, D. ; Hasse, B. ; Hirsch, H H. ; Hoffmann, M. ; Hösli, I. ; Huber, M. ; Kahlert, C. ; Kaiser, L. ; Keiser, O. ; Klimkait, T. ; Kouyos, R D. ; Kovari, H. ; Ledergerber, B. ; Martinetti, G. ; Martinez de Tejada, B. ; Marzolini, C. ; Metzner, K J. ; Müller, N. ; Nicca, D. ; Paioni, P. ; Pantaleo, G. ; Perreau, M. ; Rauch, A. ; Rudin, C. ; Scherrer, A U. ; Schmid, P. ; Speck, R. ; Stöckle, M. ; Tarr, P. ; Trkola, A. ; Vernazza, P. ; Wandeler, G. ; Weber, R. ; Yerly, S Morover ; Scherrer, Alexandra ; Wild, Susanne ; Perraudin, Danièle ; Minichiello, Mirjam ; Anagnostopoulos, A. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Braun, D L. ; Bucher, H C. ; Calmy, A. ; Cavassini, M. ; Ciuffi, A. ; Dollenmaier, G. ; Egger, M. ; Elzi, L. ; Fehr, J. ; Fellay, J. ; Furrer, H. ; Fux, C A. ; Günthard, H F. ; Haerry, D. ; Hasse, B. ; Hirsch, H H. ; Hoffmann, M. ; Hösli, I. ; Huber, M. ; Kahlert, C. ; Kaiser, L. ; Keiser, O. ; Klimkait, T. ; Kouyos, R D. ; Kovari, H. ; Ledergerber, B. ; Martinetti, G. ; Martinez de Tejada, B. ; Marzolini, C. ; Metzner, K J. ; Müller, N. ; Nicca, D. ; Paioni, P. ; Pantaleo, G. ; Perreau, M. ; Rauch, A. ; Rudin, C. ; Scherrer, A U. ; Schmid, P. ; Speck, R. ; Stöckle, M. ; Tarr, P. ; Trkola, A. ; Vernazza, P. ; Wandeler, G. ; Weber, R. ; Yerly, S Morover

In: Virus Evolution, 2018, vol. 4, no. 2, p. -

SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination

Daddacha, Waaqo ; Koyen, Allyson E. ; Bastien, Amanda J. ; Head,Pamela Sara E. ; Dhere, Vishal R. ; Nabeta, Geraldine N. ; Connolly, Erin C. ; Werner, Erica ; Madden, Matthew Z. ; Daly, Michele B. ; Minten, Elizabeth V. ; Whelan, Donna R. ; Schlafstein, Ashley J. ; Zhang, Hui ; Anand, Roopesh ; Doronio, Christine ; Withers, Allison E. ; Shepard, Caitlin ; Sundaram, Ranjini K. ; Deng, Xingming ; Dynan, William S. ; Wang, Ya ; Bindra, Ranjit S. ; Cejka, Petr ; Rothenberg, Eli ; Doetsch, Paul W. ; Kim, Baek ; Yu, David S.

In: Cell reports, 2017, vol. 20, no. 8, p. 1921-1935

DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV- 1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We show that SAMHD1 has a dNTPase-independent function in promoting DNA end resection to facilitate...