In: Arthritis research & therapy, 2018, vol. 20, p. 114
Background: B cells exert their pathogenic action in rheumatoid arthritis (RA) locally in the synovium. This study was undertaken to elucidate the chemokines responsible for the recruitment of B cells in the inflamed synovium, taking into account that the rich chemokine milieu present in the synovial tissue can fine-tune modulate discrete chemokine receptors. Methods: Expression levels of...
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In: Frontiers in immunology, 2018, vol. 9, p. 2118
Chemokine synergy-inducing molecules are emerging as regulating factors in cell migration. The alarmin HMGB1, in its reduced form, can complex with CXCL12 enhancing its activity on monocytes via the chemokine receptor CXCR4, while the form containing a disulfide bond, by binding to TLR2 or TLR4, initiates a cascade of events leading to production of cytokines and chemokines. So far, the...
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Thèse de doctorat : Università della Svizzera italiana, 2014 ; 2014COM008.
Chronic pain sufferers with diseases such as Rheumatoid Arthritis (RA) are a category of patients that feels stigmatized, lacking understanding and support from the surrounding social environment (Davison et al., 2000). The invisible and unpredictable character of RA makes it very difficult to be recognized and understood by family, friends, colleagues, and so on, and patients often complain...
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