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Università della Svizzera italiana

Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus

Biajoux, Vincent ; Bignon, Alexandre ; Freitas, Christelle ; Martinez, Valérie ; Thelen, Marcus ; Lima, Guadalupe ; Jakez-Ocampo, Juan ; Emilie, Dominique ; Llorente, Luis ; Balabanian, Karl

In: Journal of translational medicine, 2012, vol. 10, no. 1, p. 251-267

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by B-cell hyperreactivity and the production of pathogenic anti-nuclear- directed auto-antibodies (Abs). B-cell ontogeny is partly dependent on the CXCL12/CXCR4 axis for which the contribution to SLE pathogenesis remains unclear. CXCR7, the novel receptor for CXCL12, is differentially expressed among...