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Polarization of migrating monocytic cells is independent of PI 3-Kinase activity

Volpe, Silvia ; Thelen, Sylvia ; Pertel. Thomas ; Lohse, Martin J. ; Thelen, Marcus

In: Plos one, 2010, vol. 5, no. 4, p. e10159

Background: Migration of mammalian cells is a complex cell type and environment specific process. Migrating hematopoietic cells assume a rapid amoeboid like movement when exposed to gradients of chemoattractants. The underlying signaling mechanisms remain controversial with respect to localization and distribution of chemotactic receptors within the plasma membrane and the role of PI 3-kinase...