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Antibody binding modulates conformational exchange in domain III of dengue virus E protein

Moraes, Adolfo H. ; Simonelli, Luca ; Pedotti, Mattia ; Almeida, Fabio C.L. ; Varani, Luca ; Valente, Ana P.

In: Journal of virology, 2016, vol. 90, no. 4, p. 1802-1811

Domain III of dengue virus E protein (DIII) participates in the recognition of cell receptors and in structural rearrangements required for membrane fusion and ultimately viral infection; furthermore, it contains epitopes for neutralizing antibodies and has been considered a potential vaccination agent. In this work, we addressed various structural aspects of DIII and their relevance for both...