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Université de Neuchâtel

Protective immunity against Ixodes ricinus induced by a salivary serpin

Prevot, Pierre-Paul ; Couvreur, B. ; Denis, V. ; Brossard, Michel ; Vanhamme, L. ; Godfroid, E.

In: Vaccine, 2007, vol. 25, no. 17, p. 3284-3292

Iris is a specific elastase inhibitor expressed in the salivary glands of the hard tick Ixodes ricinus. It belongs to the superfamily of serpins and interferes with both haemostasis and the immune response of the host. In this study, we first show that Iris is expressed in nymphs but not in the female midgut nor in males. We also show that Iris is present in the saliva. To examine its...