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Université de Neuchâtel

Performance of an Integrated Microoptical System for Fluorescence Detection in Microfluidic Systems

Roulet , Jean-Christophe ; Völkel, Reinhard ; Herzig, Hans Peter ; Verpoorte, Elisabeth ; de Rooij, Nicolaas F. ; Dändliker, René

In: Analytical Chemistry, 2020, vol. 74, no. 14, p. 3400-3407

This article presents a new integrated microfluidic/microoptic device designed for basic biochemical analysis. The microfluidic network is wet-etched in a Borofloat 33 (Pyrex) glass wafer and sealed by means of a second wafer. Unlike other similar microfluidic systems, elements of the detection system are realized with the help of microfabrication techniques and directly deposited on both sides...

Université de Neuchâtel

Development of an Array of Ion-Selective Microelectrodes Aimed for the Monitoring of Extracellular Ionic Activities

Guenat, Olivier T. ; Generelli, Silvia ; de Rooij, Nicolaas F. ; Koudelka-Hep, Milena ; Berthiaume, François ; Yarmush, Martin L.

In: Analytical Chemistry, 2006, vol. 78, no. 21, p. 7453–7460

In this study, we present the development and the characterization of a generic platform for cell culture able to monitor extracellular ionic activities (K+, NH4+) for real-time monitoring of cell-based responses, such as necrosis, apoptosis, or differentiation. The platform for cell culture is equipped with an array of 16 silicon nitride micropipet-based...

Université de Neuchâtel

Microfabricated Chip-Scale Rubidium Plasma Light Source for Miniature Atomic Clocks

Venkatraman, Vinu ; Pétremand, Yves ; Affolderbach, Christoph ; Mileti, Gaetano ; de Rooij, Nicolaas F. ; Shea, Herbert

In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2012, vol. 59, no. 3, p. 448-456

We present the microfabrication and characterization of a low-power, chip-scale Rb plasma light source, designed for optical pumping in miniature atomic clocks. A dielectric barrier discharge (DBD) configuration is used to ignite a Rb plasma in a micro-fabricated Rb vapor cell on which external indium electrodes were deposited. The device is electrically driven at frequencies between 1 and 36...

Université de Neuchâtel

Microfabricated rubidium vapour cell with a thick glass core for small-scale atomic clock applications

Pétremand, Yves ; Affolderbach, Christoph ; Straessle, Rahel ; Pellaton, Matthieu ; Briand, Danick ; Mileti, Gaetano ; de Rooij, Nicolaas F.

In: JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2012, vol. 22, no. 2, p. 025013 (8pp)

This paper presents a new fabrication method to manufacture alkali reference cells having dimensions larger than standard micromachined cells and smaller than glass-blown ones, for use in compact atomic devices such as vapour-cell atomic clocks or magnetometers. The technology is based on anodic bonding of silicon and relatively thick glass wafers and fills a gap in cell sizes and technologies...

Université de Neuchâtel

Study of laser-pumped double-resonance clock signals using a microfabricated cell

Pellaton, Matthieu ; Affolderbach, Christoph ; Pétremand, Yves ; de Rooij, Nicolaas F. ; Mileti, Gaetano

In: Physica Scripta, 2012, vol. T149, p. 014013 (4pp)

We present our microwave spectroscopic studies on laser–microwave double-resonance (DR) signals obtained from a micro-fabricated Rb vapor cell. This study focuses on the characteristics and systematic shifts of the ground-state 'clock transition' in 87Rb (|Fg = 1, mF = 0⟩ → | Fg = 2, mF = 0⟩) used in Rb...

Université de Neuchâtel

Evaluation of the frequency stability of a VCSEL locked to a micro-fabricated Rubidium vapour cell

Di Francesco, Joab F. ; Gruet, Florian ; Schori, Christian ; Affolderbach, Christoph ; Matthey, Renaud ; Mileti, Gaetano ; Salvadé, Y. ; de Rooij, Nicolaas F. ; Petremand, Y.

In: Semiconductor Lasers and Laser Dynamics IV, 2010, vol. 7720, no. 77201T, p. 1-9

We present our evaluation of a compact laser system made of a 795 nm VCSEL locked to the Rubidium absorption line of a micro-fabricated absorption cell. The spectrum of the VCSEL was characterised, including its RIN, FM noise and line-width. We optimised the signal-to-noise ratio and determined the frequency shifts versus the cell temperature and the incident optical power. The frequency...

Université de Neuchâtel

Thermally activated solvent bonding of polymers

Ng, S. H. ; Tjeung, R. T. ; Wang, Z. F. ; Lu, A. C. W. ; Rodriguez, I. ; de Rooij, Nicolaas F.

In: Microsystem Technologies, 2008, vol. 14, no. 6, p. 753-759

We present a thermally activated solvent bonding technique for the formation of embedded microstructures in polymer. It is based on the temperature dependent solubility of polymer in a liquid that is not a solvent at room temperature. With thermal activation, the liquid is transformed into a solvent of the polymer, creating a bonding capability through segmental or chain interdiffusion at the...

Université de Neuchâtel

Development of a multi-layer microelectrofluidic platform

Ng, S. H. ; Wang, Z. F. ; Tjeung, R. T. ; de Rooij, Nicolaas F.

In: Microsystem Technologies, 2007, vol. 13, no. 11-12, p. 1509-1515

We report on recent advances in micro fabrication technology using micromoulding and high-aspect ratio structuring of photopolymer. The direct application is the realization of components for millimeter-size, ultrasonic piezoelectric motors. A new fabrication process using a thick epoxy-based material (SU-8) and the electroplating of nickel is demonstrated. Photopolymer structures have also been...

Université de Neuchâtel

Two steps micromoulding and photopolymer high-aspect ratio structuring for applications in piezoelectric motor components

Dellmann, Laurent ; Roth, S. ; Beuret, C. ; Paratte, L. ; Racine, G.-A. ; Lorenz, H. ; Despont, M. ; Renaud, Philippe ; Vettiger, Peter ; de Rooij, Nicolaas F.

In: Microsystem Technologies, 1998, vol. 4, no. 3, p. 147-150

We report on recent advances in micro fabrication technology using micromoulding and high-aspect ratio structuring of photopolymer. The direct application is the realization of components for millimeter-size, ultrasonic piezoelectric motors. A new fabrication process using a thick epoxy-based material (SU-8) and the electroplating of nickel is demonstrated. Photopolymer structures have also been...

Université de Neuchâtel

Fabrication and electroosmotic flow measurements in micro- and nanofluidic channels

Hug, Thomas S. ; de Rooij, Nicolaas F. ; Staufer, Urs

In: Microfluidics and Nanofluidics, 2006, vol. 2, no. 2, p. 117-124

An easy method for fabricating micro- and nanofluidic channels, entirely made of a thermally grown silicon dioxide is presented. The nanochannels are up to 1-mm long and have widths and heights down to 200 nm, whereas the microfluidic channels are 20-μm wide and 4.8-μm high. The nanochannels are created at the interface of two silicon wafers. Their fabrication is based on the expansion of...