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Université de Neuchâtel

Lyme disease

Gern, Lise ; Falco, R.C

In: Scientific and Technical Review of the Office International des Epizooties, 2000, vol. 19, no. 1, p. 121-135

La borréliose de Lyme qui est, dans l'hémisphère nord, la plus répandue des maladies à transmission vectorielle, est due à des bactéries appartenant au genre Borrelia burgdorferi. Il s'agit d'une maladie plurisystémique qui affecte essentiellement la peau, le système nerveux le cœur et les articulations. En Europe, le vecteur de la maladie est la tique Ixodes ricinus; aux...

Université de Neuchâtel

Tiques et borréliose de Lyme en Suisse occidentale

Gern, Lise

In: Bulletin de la Société Neuchâteloise des Sciences Naturelles, 2004, vol. 127, p. 5-21

La maladie de Lyme est une maladie dont l'agent responsable, une bactérie, Borrelia burgdorferi, n'a été découvert qu'au début des années 1980. Elle se manifeste de manière proteiforme et provoque des manifestations dermatologiques, neurologiques, cardiaques ainsi que des arthrites. Trois espèces de bactéries, B. burgdorferi s.s. , B. garinii et B. afzelii...

Université de Neuchâtel

Protective immunization with plasmid DNA containing the outer surface lipoprotein A gene of Borrelia burgdorferi is independent of an eukaryotic promoter

Simon, Markus M ; Gern, Lise ; Hauser, Pierre ; Zhong, Weimin ; Nielsen, Peter J ; Kramer, Michael D ; Brenner, Christiane ; Wallich, Reinhard

In: European Journal of Immunology, 1996, vol. 26, no. 12, p. 2831-2840

Plasmid DNA encoding the outer surface lipoprotein A (OspA) of Borrelia burgdorferi under the control of either strong eukaryotic/viral or its own bacterial promoter was injected intramuscularly (m. tibialis anterior) or intradermally into BALB/c and AKR/N mice. OspA-specific antibodies and OspA-reactive T helper 1 cells (Th1) were induced only with those plasmids containing the...

Université de Neuchâtel

The Ecology of Lyme Borreliosis in the UK

Nuttall, Patricia ; Randolph, Sarah ; Carey, Dorothy ; Craine, Noel ; Livesley, Anne ; Gern, Lise

In: Lyme Borreliosis / ed. by Axford, John S. and Rees, David H. E., 1994, vol. 260, p. 125-129

Université de Neuchâtel

Rickettsia-like microorganisms in the ovarian primordial of molting Ixodes ricinus (acari : ixodidae) larvae and nymphs

Zhu, Z ; Aeschlimann, André ; Gern, Lise

In: Annales de parasitologie humaine et comparée, 1992, vol. 67, no. 4, p. 99-110

Un grand nombre de micro-organismes de type rickettsien ont été observés dans les cellules des ébauches ovariennes de larves et de nymphes d'Ixodes ricinus, lors de la mue. La morphologie de ces organismes est identique chez toutes les tiques examinées. Ils mesurent 0,3-0,4 µm de diamètre et 0,6-1,3 µm, parfois jusqu’à 2,5 µm, de long. Ils possèdent une paroi externe...

Université de Neuchâtel

T helper cell priming of mice to Borrelia burgdorferi Osp A leads to induction of protective antibodies following experimental but not tickborne infection

Zhong, Weimin ; Gern, Lise ; Kramer, Michael ; Wallich, Reinhard ; Simon, Markus M

In: European Journal of Immunology, 1997, vol. 27, no. 11, p. 2942-2947

Antibodies to the outer surface lipoprotein A (Osp A) of Borrelia burgdorferi confer protection to SCID mice against subsequent tick-borne or experimental infection. However, Osp A-specific antibodies are hardly detectable in naturally infected humans, dogs, hamsters and mice. This is most probably due to limited expression of Osp A on spirochetes transmitted from the vector to the...

Université de Neuchâtel

Mode of inoculation of the Lyme disease agent Borrelia burgdorferi influences infection and immune responses in inbred strains of mice

Gern, Lise ; Schaible, Ulrich E ; Simon, Markus M

In: The Journal of Infectious Diseases, 1993, vol. 167, no. 4, p. 971-975

Mice were infected with Borrelia burgdorferi by infection via Ixodes ricinus and experimental inoculation to determine whether transmission rates of spirochetes and antibody responses are influenced. Mice infected by the natural route were substantially more infective for ticks; two- to sixfold more tick larvae were positive for B. burgdorferi than those fed on experimentally...

Université de Neuchâtel

Resolution of experimental and tick-borne Borrelia burgdorferi infection in mice by passive, but not active immunization using recombinant OspC

Zhong, Weimin ; Gern, Lise ; Stehle, Thomas ; Museteanu, Crisan ; Kramer, Michael ; Wallich, Reinhard ; Simon, Markus M

In: European Journal of Immunology, 1999, vol. 29, no. 3, p. 946-957

Vaccination with outer surface protein A (OspA) of Borrelia burgdorferi prevents subsequent infection and disease in both laboratory animals and humans with high efficacy. OspA-based immunity, however, does not affect established infection due to the loss of OspA expression in the vertebrate host. We show here that repeated passive transfer of mouse and/or rabbit immune sera to...

Université de Neuchâtel

Borrelia burgdorferi in a focus of Lyme borreliosis: epizootiologic contribution of small mammals

Humair, Pierre-François ; Turrian, N ; Aeschlimann, André ; Gern, Lise

In: Folia Parasitologica, 1993, vol. 40, no. 1, p. 65-70

The contribution of woodmice (Apodemus sylvaticus), yellow-necked mice (Apodemus flavicollis) and bank voles (Clethrionomys glareolus) was compared in a focus of Lyme borreliosis in Switzerland during a 7 months' study. All three species of mice and one species of shrews (Sorex araneus) were shown parasitized by infected Ixodes ricinus immatures. About 14% of...