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Université de Neuchâtel

Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles

Mattsson, Johan ; Govindaswamy, Padavattan ; Renfrew, Anna K. ; Dyson, Paul J. ; Štěpnička, Petr ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 15, p. 4350–4357

The cytotoxicities of a new series of cationic metallarectangles have been established in the A2780 ovarian cancer cell line. Interestingly, the large rectangles incorporating 1,2-bis(4-pyridyl)ethylene linkers are ca. 5 times more cytotoxic (IC50 ≤ 6 μM) than the 4,4-bipyridine analogues (IC50 ≥ 30 μM), thus suggesting a correlation between cytotoxicity and the size...

Université de Neuchâtel

Template-Directed Synthesis of Hexanuclear Arene Ruthenium Complexes with Trigonal-Prismatic Architecture Based on 2,4,6-Tris(3-pyridyl)triazine Ligands

Freudenreich, Julien ; Furrer, Julien ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2011, vol. 30, no. 5, p. 942–951

Cationic arene ruthenium metalla-prisms of the general formula [Ru6(p-cymene)6(3-tpt)2(OO∩OO)3]6+ (3-tpt = 2,4,6-tris(3-pyridyl)-1,3,5-triazine; OO∩OO = 5,8-dioxido-1,4-naphthoquinonato [1]6+ or 6,11-dioxido-5,12-naphthacenedionato [2]6+) have been obtained from the corresponding...

Université de Neuchâtel

Highly Efficient NMR Enantiodiscrimination of Chiral Octanuclear Metalla-Boxes in Polar Solvent

Barry, Nicolas P.E. ; Austeri, Martina ; Lacour, Jerôme ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 16, p. 4894–4897

Detection of the molecular chirality of a series of octanuclear metalla-boxes can be readily achieved using the NMR chiral solvating agent Λ-BINPHAT in CD3CN: only 0.05 to 0.10 equiv being necessary for a complete baseline separation of some of the proton signals.

Université de Neuchâtel

Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers

Schmitt, Frédéric ; Freudenreich, Julien ; Barry, Nicolas P.E. ; Juillerat-Jeanneret, Lucienne ; Süss-Fink, Georg ; Therrien, Bruno

In: Journal of the American Chemical Society (JACS), 2012, vol. 134, no. 2, p. 754-757

Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new strategy to tackle overall photosensitization, a limitation often encountered in photodynamic...

Université de Neuchâtel

Synthesis and characterization of fullerene-pyridyl arene ruthenium complexes

Appavoo, Divambal ; Deschenaux, Robert ; Therrien, Bruno

In: Studia Universitatis Babes-Bolyai. Chemia, 2015, vol. 60, no. 4, p. 229-238

Association of [60]fullerene with arene ruthenium moieties has been achieved for the first time. Two fullerenopyrrolidine derivatives (Npyr-C60) were synthesized via a 1,3-dipolar cycloaddition, and coordinated to arene ruthenium complexes to form two half-sandwich complexes of the general formula...

Université de Neuchâtel

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Pitto-Barry, Anaïs ; Zava, Olivier ; Dyson, Paul J ; Deschenaux, Robert ; Therrien, Bruno

In: Inorganic Chemistry, 2012, vol. 51, no. 13, p. 7119-7124

Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrGn) or alcohol (pyrGn-OH) (n = 1–3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metallacages, [Ru6(p-cymene) 6 (OO∩OO)3(tpt)2]6+ (OO∩OO =...

Université de Neuchâtel

Designing Supramolecular Liquid-Crystalline Hybrids from Pyrenyl-Containing Dendrimers and Arene Ruthenium Metallacycles

Pitto-Barry, Anaïs ; Barry, Nicolas P. E ; Russo, Virginie ; Heinrich, Benoît ; Donnio, Bertrand ; Therrien, Bruno ; Deschenaux, Robert

In: Journal of the American Chemical Society, 2014, vol. 136, no. 50, p. 17616-17625

The association of the arene ruthenium metallacycle [Ru4(p- cymene)4(bpe)2(donq)2][DOS]4 (bpe = 1,2- bis(4-pyridyl)ethylene, donq = 5,8-dioxydo-1,4-naphtoquinonato, DOS = dodecyl sulfate) with pyrenyl-functionalized poly(arylester) dendrimers bearing cyanobiphenyl end- groups is reported. The supramolecular dendritic systems display...

Université de Neuchâtel

NMR spectroscopy and DFT calculations of a self-assembled arene ruthenium rectangle obtained from a combination of coordination and hydrogen bonds

Appavoo, Divambal ; Raja, Nandhagopal ; Deschenaux, Robert ; Therrien, Bruno ; Carnevale, Diego

In: Dalton Transactions, 2016, vol. 45, no. 4, p. 1410-1421

The hydrogen-bonded arene ruthenium metalla-rectangle, [(p-cymene) 2Ru2(OOnOO)(UPy)2]24+ , obtained from 1-(4-oxo-6-undecyl-1,4-dihydropyrimidin-2-yl)-3-(pyridin-4- ylmethyl)urea (UPy) and the dinuclear arene ruthenium clip (p-cymene) 2Ru2(OOnOO)Cl2 (OOnOO = 2,5-dioxido-1,4- benzoquinonato), is investigated by...

Université de Neuchâtel

Combining coordination and hydrogen-bonds to form arene ruthenium metalla-assemblies

Appavoo, Divembal ; Carnevale, Diego ; Deschenaux, Robert ; Therrien, Bruno

In: Journal of Organometallic Chemistry, 2016, vol. 824, p. 80-87

Three ureido-pyrimidone derivatives (N-LH) were used to generate in combination with four dinuclear arene ruthenium clips, (p-cymene) 2Ru2(OO boolean AND OO)Cl2 (OO boolean AND OO = oxalato, 2,5-dioxido-1,4-benzoquinonato, 2,5-dichloro-1,4-benzoquinonato, 5,8-dioxido-1,4-naphtoquinonato), twelve cationic arene ruthenium metalla-cycles of the...

Université de Neuchâtel

Thiolato-Bridged Arene–Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2 (SR)2Cl2]

Ibao, Anne-Flore ; Gras, Michaël ; Therrien, Bruno ; Süss-Fink, Georg ; Zava, Olivier ; Dyson, Paul J.

In: European Journal of Inorganic Chemistry, 2012, vol. 2012, no. 9, p. 1531-1535

Treatment of an arene–ruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene) 2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and characterized for arene =...