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Université de Neuchâtel

Diversity within Borrelia burgdorferi sensu lato genospecies in Switzerland by recA gene sequence

Casati, Simona ; Bernasconi, Marco V. ; Gern, Lise ; Piffaretti, Jean-Claude

In: FEMS Microbiology Letters, 2004, vol. 238, p. 115-123

A total of 874 Ixodes ricinus ticks were collected in Switzerland to investigate the genetic diversity of the Borrelia population. We integrated to the RT-PCR method the DNA sequence analysis of a 162-bp fragment of the recA gene. Five genospecies were detected: Borrelia afzelii, Borrelia burgdorferi s.s., Borrelia garinii, Borrelia valaisiana, and...

Université de Neuchâtel

Assessment of intraspecific mtDNA variability of European Ixodes ricinus sensu stricto (Acari: Ixodidae)

Casati, Simona ; Bernasconi, Marco V. ; Gern, Lise ; Piffaretti, Jean-Claude

In: Infection, Genetics and Evolution, 2008, vol. 8, no. 2, p. 152-158

The Ixodes ricinus complex is composed of 14 species distributed worldwide. Some members of this complex are involved in the transmission of a number of diseases to animals and humans, in particular Lyme borreliosis, tick-borne encephalitis, ehrlichiosis and babesiosis. While the phylogenetic relationships between species of the I. ricinus complex have been investigated in the past,...

Université de Neuchâtel

Investigations on the Mode and Dynamics of Transmission and Infectivity of Borrelia burgdorferi Sensu Stricto and Borrelia afzelii in Ixodes ricinus Ticks

Crippa, Mara ; Rais, Olivier ; Gern, Lise

In: Vector Borne Zoonotic Diseases, 2002, vol. 2, no. 1, p. 3-9

Borrelia burgdorferi sensu lato (sl), the agent of Lyme disease, is transmitted to the host during the blood meal of Ixodes ticks. In most unfed ticks, spirochetes are present in the midgut and migrate during blood feeding to the salivary glands, from which they are transmitted to the host via saliva. In the present study, the efficiency of Ixodes ricinus ticks to transmit...

Université de Neuchâtel

Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins

Daix, V. ; Schroeder, H. ; Praet, N. ; Georgin, J.-P. ; Chiappino, I. ; Gillet, L. ; de Fays, K. ; Decrem, Y. ; Leboulle, G. ; Godfroid, E. ; Bollen, A. ; Pastoret, P.-P. ; Gern, Lise ; Sharp, P. M. ; Vanderplasschen, A.

In: Insect Molecular Biology, 2007, vol. 16, no. 2, p. 155-166

The alternative pathway of complement is an important innate defence against pathogens including ticks. This component of the immune system has selected for pathogens that have evolved countermeasures. Recently, a salivary protein able to inhibit the alternative pathway was cloned from the American tick Ixodes scapularis (Valenzuela et al., 2000; J. Biol. Chem. 275, 18717–18723)....