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Université de Fribourg

Robust climate scenarios for sites with sparse observations: a two-step bias correction approach

Rajczak, Jan ; Kotlarski, Sven ; Salzmann, Nadine ; Schär, Christoph

In: International Journal of Climatology, 2016, vol. 36, no. 3, p. 1226–1243

Observed and projected climatic changes demand for robust assessments of climate impacts on various environmental and anthropogenic systems. Empirical-statistical downscaling (ESD) methods coupled to output from climate model projections are promising tools to assess impacts at regional to local scale. ESD methods correct for common model deficiencies in accuracy (e.g. model biases) and scale...

Université de Fribourg

A review of the fossil record of turtles of the clade Pan-Chelydridae

Joyce, Walter G.

In: Bulletin of the Peabody Museum of Natural History, 2016, vol. 57, no. 1, p. 21–56

Turtles of the total clade Pan-Chelydridae have a relatively sparse fossil record that reaches back to the Late Cretaceous (Santonian). The clade was only present in North America during the Cretaceous but spread along unclear routes to Asia and Europe during the Paleocene, only to go extinct on those continents by the end of the Pliocene. Final dispersal to South America took place at some time...

Université de Fribourg

A Review of the fossil record of turtles of the clade Pan-Kinosternoidea

Joyce, Walter G. ; Bourque, Jason R.

In: Bulletin of the Peabody Museum of Natural History, 2016, vol. 57, no. 1, p. 57–95

Turtles of the total clade Pan-Kinosternoidea have a relatively poor fossil record that extends back to the Late Cretaceous (Campanian). The clade is found only in North America during its early history, but dispersed to Central America no later than the Miocene and to South America no later than the Pleistocene. Ancestral pan-kinosternoids were likely aquatic, bottom-walking omnivores or...

Université de Fribourg

Sensitivity of very small glaciers in the Swiss Alps to future climate change

Huss, Matthias ; Fischer, Mauro

In: Cryospheric Sciences, 2016, p. 34

Very small glaciers (<0.5 km2) account for more than 80% of the total number of glaciers in mid- to low-latitude mountain ranges. Although their total area and volume is small compared to larger glaciers, they are a relevant component of the cryosphere, contributing to landscape formation, local hydrology, and sea-level rise. Worldwide glacier monitoring mostly focuses on medium-sized to large...

Université de Fribourg

First description of a fossil chamaeleonid from Greece and its relevance for the European biogeographic history of the group

Georgalis, Georgios L. ; Villa, Andrea ; Delfino, Massimo

In: The Science of Nature, 2016, vol. 103, no. 1–2, p. 1–12

The fossil record of Chamaeleonidae is very scarce and any new specimen is therefore considered important for our understanding of the evolutionary and biogeographic history of the group. New specimens from the early Miocene of Aliveri (Evia Island), Greece constitute the only fossils of these lizards from southeastern Europe. Skull roofing material is tentatively attributed to the Czech species...

Université de Fribourg

Heme oxygenase-1/carbon monoxide system and embryonic stem cell differentiation and maturation into cardiomyocytes

Suliman, Hagir B. ; Zobi, Fabio ; Piantadosi, Claude A.

In: Antioxidants & Redox Signaling, 2016, vol. 24, no. 7, p. 345–360

The differentiation of embryonic stem (ES) cells into energetically efficient cardiomyocytes contributes to functional cardiac repair and is envisioned to ameliorate progressive degenerative cardiac diseases. Advanced cell maturation strategies are therefore needed to create abundant mature cardiomyocytes. In this study, we tested whether the redox-sensitive heme oxygenase-1/carbon monoxide...

Université de Fribourg

Engineered nanomaterials: toward effective safety management in research laboratories

Groso, Amela ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hofmann, Heinrich ; Meyer, Thierry

In: Journal of Nanobiotechnology, 2016, vol. 14, p. 21

It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is available. To deal with the rapid evolution of research, including the fast turnover of collaborators, a user-friendly and easy-to-apply risk...

Université de Fribourg

The first phospho­ramide-mercury(II) complex with a Cl₂Hg-OP[N(C)(C)]₃ segment

Saneei, Anahid ; Pourayoubi, Mehrdad ; Crochet, Aurelien ; Fromm, Katharina M.

In: Acta Crystallographica C, 2016, vol. 72, p. 230-233

Mercury(II) exhibits a strong preference for linear coordination which has been attributed to relativistic effects splitting the 6p orbitals and promoting sp hybridization. If the two ligands attached to the mercury(II) ion are weak donors, the metal ion can act as a good Lewis acid and expand its coordination number. Moreover, mercury has a special affinity for softer bases,...

Université de Fribourg

Altered sleep homeostasis in rev-erbα knockout mice

Mang, Géraldine M. ; La Spada, Francesco ; Emmenegger, Yann ; Chappuis, Sylvie ; Ripperger, Jürgen A. ; Albrecht, Urs ; Franken, Paul

In: SLEEP, 2016, vol. 39, no. 3, p. 589–601

Study Objectives: The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of...

Université de Fribourg

An approximate Markov model for the wright-fisher diffusion and its application to time series data

Ferrer-Admetlla, Anna ; Leuenberger, Christoph ; Jensen, Jeffrey D. ; Wegmann, Daniel

In: Genetics, 2016, p. -

The joint and accurate inference of selection and demography from genetic data is considered a particularly challenging question in population genetics, since both process may lead to very similar patterns of genetic diversity. However, additional information for disentangling these effects may be obtained by observing changes in allele frequencies over multiple time points. Such data is...