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Université de Fribourg

Basal forebrain contributes to default mode network regulation

Nair, Jayakrishnan ; Klaassen, Arndt-Lukas ; Arato, Jozsef ; Vyssotski, Alexei L. ; Harvey, Michael ; Rainer, Gregor

In: Proceedings of the National Academy of Sciences, 2018, vol. 115, no. 6, p. 1352–1357

The default mode network (DMN) is a collection of cortical brain regions that is active during states of rest or quiet wakefulness in humans and other mammalian species. A pertinent characteristic of the DMN is a suppression of local field potential gamma activity during cognitive task performance as well as during engagement with external sensory stimuli. Conversely, gamma activity is...

Université de Fribourg

Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate–glutamine cycle in the tree shrew visual cortex

Sonnay, Sarah ; Poirot, Jordan ; Just, Nathalie ; Clerc, Anne-Catherine ; Gruetter, Rolf ; Rainer, Gregor ; Duarte, João M. N.

In: Glia, 2018, vol. 66, no. 3, p. 477–491

Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple to that of glucose utilization and of neuronal tricarboxylic acid (TCA) cycle. In this study, we tested the hypothesis that glutamatergic...

Université de Fribourg

Malaria infected red blood cells release small regulatory RNAs through extracellular vesicles

Babatunde, Kehinde Adebayo ; Mbagwu, Smart ; Hernández-Castañeda, María Andrea ; Adapa, Swamy R. ; Walch, Michael ; Filgueira, Luis ; Falquet, Laurent ; Jiang, Rays H. Y. ; Ghiran, Ionita ; Mantel, Pierre-Yves

In: Scientific Reports, 2018, vol. 8, no. 1, p. 884

The parasite Plasmodium falciparum causes the most severe form of malaria. Cell communication between parasites is an important mechanism to control population density and differentiation. The infected red blood cells (iRBCs) release small extracellular vesicles (EVs) that transfer cargoes between cells. The EVs synchronize the differentiation of the asexual parasites into gametocytes to...

Université de Fribourg

Exploring three different expression systems for recombinant expression of globins: Escherichia coli, Pichia pastoris and Spodoptera frugiperda

Bracke, An ; Hoogewijs, David ; Dewilde, Sylvia

In: Analytical Biochemistry, 2018, vol. 543, p. 62–70

Globins are among the best investigated proteins in biological and medical sciences and represent a prime tool for the study of the evolution of genes and the structure- function relationship of proteins. Here, we explore the recombinant expression of globins in three different expression systems: Escherichia coli, Pichia pastoris and the baculovirus infected Spodoptera frugiperda. We...

Université de Fribourg

Exploring three different expression systems for recombinant expression of globins: Escherichia coli, Pichia pastoris and Spodoptera frugiperda

Bracke, An ; Hoogewijs, David ; Dewilde, Sylvia

In: Analytical Biochemistry, 2018, vol. 543, p. 62–70

Globins are among the best investigated proteins in biological and medical sciences and represent a prime tool for the study of the evolution of genes and the structure- function relationship of proteins. Here, we explore the recombinant expression of globins in three different expression systems: Escherichia coli, Pichia pastoris and the baculovirus infected Spodoptera frugiperda. We...

Université de Fribourg

Myocardial infarction does not affect circulating haematopoietic stem and progenitor cell self‐renewal ability in a rat model

Kröpfl, J. M. ; Spengler, C. M. ; Frobert, Aurelien ; Ajalbert, Guillaume ; Giraud, Marie-Noëlle

In: Experimental Physiology, 2018, vol. 103, no. 1, p. 1–8

Given the importance of peripheral blood haematopoietic stem and progenitor cells (HPCs) in post-acute regeneration after acute myocardial infarction (MI), the aim of the present study was to investigate the number and secondary replating capacity/self-renewal ability of HPCs in peripheral blood before and 2 weeks after MI. In female Lewis inbred rats (n = 9), MI was induced by ligation of...

Université de Fribourg

Experience from an optional dissection course in a clinically‐orientated concept to complement system‐based anatomy in a reformed curriculum

Eppler, Elisabeth ; Serowy, Steffen ; Link, Karl ; Filgueira, Luis

In: Anatomical Sciences Education, 2018, vol. 11, no. 1, p. 32–43

Profound anatomical knowledge is the basis for modern demands in medicine and surgery, but many countries worldwide including Australia and New Zealand have discontinued offering dissection courses to medical and dental students during the past decades. This educational project done in Australia aimed at enhancing basic and advanced anatomy teaching by engaging a sub-group of second-year ...

Université de Fribourg

The dynamics of media business models: innovation, versioning and blended media

Badillo, Patrick-Yves ; Bourgeois, Dominique

In: The Media Industries and their Markets – Quantitative Analyses, 2010, p. 64-86