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Université de Fribourg

Asymmetric and distant effects of a unilateral lesion of the primary motor cortex on the bilateral supplementary motor areas in adult macaque monkeys

Contestabile, Alessandro. ; Colangiulo, R. ; Lucchini, Matteo ; Gindrat, Anne-Dominique ; Hamadjida, Adjia ; Kaeser, Mélanie ; Savidan, Julie ; Wyss, A. F. ; Rouiller, Eric M. ; Schmidlin, Eric

In: Journal of Neuroscience, 2018, vol. 38, no. 50, p. 10644–10656

A restricted lesion of the hand area in the primary motor cortex (M1) leads to a deficit of contralesional manual dexterity, followed by an incomplete functional recovery, accompanied by plastic changes in M1 itself and in other cortical areas on both hemispheres. Using the marker SMI-32 specific to pyramidal neurons in cortical layers III and V, we investigated the impact of a focal...

Université de Fribourg

Auditory time perception in Huntington’s disease

Vez, S. ; Köhli, J. ; Frey, B. ; Magezi, David A. ; Annoni, Jean-Marie ; Burgunder, J.-M.

In: Neuropsychologia, 2018, vol. 119, p. 247–252

Huntington's disease (HD) is characterized by early involvement of the striatum. It affects the pace of repetitive motor activity, as motor timing depends on basal ganglia activity. However, data are lacking on the impact of this process on auditory time perception in motor non-affected gene carriers.Objective: This work aims to test the performance in time perception of a group of mutation...

Université de Fribourg

The representation of white matter in the central nervous system

Baud, Robert ; Sprumont, Pierre ; Donkelaar, Hans J. ten

In: Frontiers in Neuroanatomy, 2018, vol. 12, p. -

The white matter of the central nervous system (CNS) is difficult to represent in anatomy because it is located predominantly “between” other anatomical entities. In a classic presentation, like a cross section of a brain segment, white matter is present and can be labeled adequately. Several appearances of the same entity are feasible on successive cross section views. The problem is the...

Université de Fribourg

Parvalbumin alters mitochondrial dynamics and affects cell morphology

Lichvarova, Lucia ; Henzi, Thomas ; Safiulina, Dzhamilja ; Kaasik, Allen ; Schwaller, Beat

In: Cellular and Molecular Life Sciences, 2018, vol. 75, no. 24, p. 4643–4666

The Ca2+-binding protein parvalbumin (PV) and mitochondria play important roles in Ca2+ signaling, buffering and sequestration. Antagonistic regulation of PV and mitochondrial volume is observed in in vitro and in vivo model systems. Changes in mitochondrial morphology, mitochondrial volume and dynamics (fusion, fission, mitophagy) resulting from modulation of PV were investigated in MDCK...

Université de Fribourg

Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy

Eisele, Nicole ; Klossner, Rahel ; Escher, Geneviève ; Rudloff, Stefan ; Larionov, Alexey ; Theilig, Franziska ; Mohaupt, Markus G. ; Mistry, Hiten D. ; Gennari‐Moser, Carine

In: Journal of the American Heart Association, 2018, p. -

In pregnancy, a high plasma volume maintains uteroplacental perfusion and prevents placental ischemia, a condition linked to elevated maternal blood pressure (BP). Reducing BP by increasing Na+ intake via plasma volume expansion appears contra‐ intuitive. We hypothesize that an appropriate Na+ intake in pregnancy reduces maternal BP and adapts the renin‐angiotensin system in a...

Université de Fribourg

Expression pattern of delta-like 1 homolog in developing sympathetic neurons and chromaffin cells

El Faitwri, Tehani ; Huber, Katrin

In: Gene Expression Patterns, 2018, vol. 30, p. 49–54

Delta-like 1 homolog (DLK1) is a member of the epidermal growth factor (EGF)-like family and an atypical notch ligand that is widely expressed during early mammalian development with putative functions in the regulation of cell differentiation and proliferation. During later stages of development, DLK1 is downregulated and becomes increasingly restricted to specific cell types, including...

Université de Fribourg

Expression of granulisyn, perforin and granzymes in human milk over lactation and in the case of maternal infection

Twigger, Alecia-Jane ; Küffer, Gwendoline K. ; Geddes, Donna T. ; Filgueria, Luis

In: Nutrients, 2018, vol. 10, no. 9, p. 1230

Human milk has been previously found to contain various types of leukocytes however specific characteristics of these cells, such as whether they contain cytolytic antimicrobial proteins that may induce pathogen directed cell death, are unknown. This project aims to examine the presence and localization of immune proteins such as perforin, granulysin and granzymes in human milk cells at the...

Université de Fribourg

Lentiviral-mediated let-7d microRNA overexpression induced anxiolytic- and anti-depressant-like behaviors and impaired dopamine D3 receptor expression

Bahi, Amine ; Dreyer, Jean-Luc

In: European Neuropsychopharmacology, 2018, vol. 28, no. 12, p. 1394–1404

Generalized anxiety and major depression disorders (MDD) are severe debilitating mood disorders whose etiology are not fully understood, but growing evidence indicates that microRNAs (miRNAs) might play a key role in their neuropathophysiological mechanisms. In the current study, we investigate the role of Lethal-7 (let-7d) miRNA, and its direct target dopamine D3 receptor (D3R) gain-of-...