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Université de Fribourg

Successful neuropsychological rehabilitation in a patient with Cerebellar Cognitive Affective Syndrome

Ruffieux, N. ; Colombo, Françoise ; Gentaz, E. ; Annoni, Jean-Marie ; Chouiter, Leila ; Roulin Hefti, S. ; Ruffieux, A. ; Bihl, T.

In: Applied Neuropsychology: Child, 2017, vol. 6, no. 2, p. 180–188

The objective of this case study was to describe the neuropsychological rehabilitation of a 16-year-old patient who presented a Cerebellar Cognitive Affective Syndrome (CCAS) following a bilateral cerebellar hemorrhage. The patient presented severe and diffuse cognitive deficits, massive behavioral disorders, and emotion regulation difficulties. The cognitive rehabilitation was performed in...

Université de Fribourg

Cue recognition and integration – eye tracking evidence of processing differences in sentence comprehension in aphasia

Schumacher, Rahel ; Cazzoli, Dario ; Eggenberger, Noëmi ; Preisig, Basil ; Nef, Tobias ; Nyffeler, Thomas ; Gutbrod, Klemens ; Annoni, Jean-Marie ; Müri, René M.

In: PLoS ONE, 2015, vol. 10, no. 11, p. e0142853

We aimed at further elucidating whether aphasic patients’ difficulties in understanding non-canonical sentence structures, such as Passive or Object-Verb-Subject sentences, can be attributed to impaired morphosyntactic cue recognition, and to problems in integrating competing interpretations.Methods: A sentence-picture matching task with canonical and non-canonical spoken sentences was...

Université de Fribourg

Rivastigmine for HIV-associated neurocognitive disorders A randomized crossover pilot study

Simioni, Samanta ; Cavassini, Matthias ; Annoni, Jean-Marie ; Iglesias, Mélanie Métral, Katia ; Abraham, Aline Rimbault ; Jilek, Samantha ; Calmy, Alexandra ; Müller, Hubertus ; Fayet-Mello, Aurélie ; Giacobini, Ezio ; Hirschel, Bernard ; Pasquier, Renaud A. Du

In: Neurology, 2013, vol. 80, no. 6, p. 553–560

Objective: To assess the efficacy and safety of rivastigmine for the treatment of HIV-associated neurocognitive disorders (HAND) in a cohort of long-lasting aviremic HIV+ patients.Methods: Seventeen aviremic HIV+ patients with HAND were enrolled in a randomized, double-blind, placebo-controlled, crossover study to receive either oral rivastigmine (up to 12 mg/day for 20 weeks) followed by placebo...

Université de Fribourg

Multiple sclerosis decreases explicit counterfactual processing and risk taking in decision making

Simioni, Samanta ; Schluep, Myriam ; Bault, Nadège ; Coricelli, Giorgio ; Kleeberg, Joerg ; Pasquier, Renaud A. Du ; Gschwind, Markus ; Vuilleumier, Patrik ; Annoni, Jean-Marie

In: PLoS ONE, 2012, vol. 7, no. 12, p. e50718

Deficits in decision making (DM) are commonly associated with prefrontal cortical damage, but may occur with multiple sclerosis (MS). There are no data concerning the impact of MS on tasks evaluating DM under explicit risk, where different emotional and cognitive components can be distinguished.Methods: We assessed 72 relapsing-remitting MS (RRMS) patients with mild to moderate disease and 38...

Université de Fribourg

Brain activity during observation and motor imagery of different balance tasks: An fMRI study

Taube, Wolfgang ; Mouthon, Michael ; Leukel, Christian ; Hoogewoud, Henri-Marcel ; Annoni, Jean-Marie ; Keller, Martin

In: Cortex, 2015, vol. 64, p. 102–114

After immobilization, patients show impaired postural control and increased risk of falling. Therefore, loss of balance control should already be counteracted during immobilization. Previously, studies have demonstrated that both motor imagery (MI) and action observation (AO) can improve motor performance. The current study elaborated how the brain is activated during imagination and observation...

Université de Fribourg

Language and syntactic impairment following stroke in late bilingual aphasics

Tschirren, Muriel ; Laganaro, Marina ; Michel, Patrik ; Martory, Marie-Dominique ; Di Pietro, Marie ; Abutalebi, Jubin ; Annoni, Jean-Marie

In: Brain and Language, 2011, vol. 119, no. 3, p. 238-242

Purpose :Bilingual aphasia generally affects both languages. However, the age of acquisition of the second language (L2) seems to play a role in the anatomo-functional correlation of the syntactical/grammatical processes, thus potentially influencing the L2 syntactic impairment following a stroke. The present study aims to analyze the influence of late age of acquisition of the L2 on syntactic...

Université de Fribourg

Auditory time perception in Huntington’s disease

Vez, S. ; Köhli, J. ; Frey, B. ; Magezi, David A. ; Annoni, Jean-Marie ; Burgunder, J.-M.

In: Neuropsychologia, 2018, vol. 119, p. 247–252

Huntington's disease (HD) is characterized by early involvement of the striatum. It affects the pace of repetitive motor activity, as motor timing depends on basal ganglia activity. However, data are lacking on the impact of this process on auditory time perception in motor non-affected gene carriers.Objective: This work aims to test the performance in time perception of a group of mutation...