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Université de Fribourg

Zooming in on spatial scaling: Preschool children and adults use mental transformations to scale spaces

Möhring, Wenke ; Newcombe, Nora S. ; Frick, Andrea

In: Developmental Psychology, 2014, vol. 50, no. 5, p. 1614-1619

Spatial scaling is an important prerequisite for many spatial tasks and involves an understanding of how distances in different-sized spaces correspond. Previous studies have found evidence for such an understanding in preschoolers; however, the mental processes involved remain unclear. The present study investigated whether children and adults use mental transformations to scale distances in...

Université de Fribourg

ZHO-1, an intrinsic MBL from the environmental Gram-negative species Zhongshania aliphaticivorans

Kieffer, Nicolas ; Guzmán-Puche, Julia ; Poirel, Laurent ; Kang, Hyo Jung ; Jeon, Che Ok ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2019, vol. 74, no. 6, p. 1568–1571

Objectives: Our aim was to characterize the putative MBL of the environmental strain Zhongshania aliphaticivorans isolated from a marine environment.Methods: The putative MBL was identified in silico using the NCBI database. The β-lactamase gene was cloned into different Escherichia coli backgrounds. Kinetic parameters were determined using the purified enzyme.Results: The enzyme named ZHO-1...

Université de Fribourg

The zebrafish heart regenerates after cryoinjury-induced myocardial infarction

Chablais, Fabian ; Veit, Julia ; Rainer, Gregor ; Jaźwińska, Anna

In: BMC Developmental Biology, 2011, vol. 11, p. 21

Background: In humans, myocardial infarction is characterized by irreversible loss of heart tissue, which becomes replaced with a fibrous scar. By contrast, teleost fish and urodele amphibians are capable of heart regeneration after a partial amputation. However, due to the lack of a suitable infarct model, it is not known how these animals respond to myocardial infarction.Results: Here, we have...

Université de Fribourg

Zebrafish fin regeneration involves transient serotonin synthesis

König, Désirée ; Jaźwińska, Anna

In: Wound Repair and Regeneration, 2019, p. wrr.12719

The zebrafish is a vertebrate organism capable of regenerating many of its organs. Notably, it can undergo epimorphic regeneration of its fins after amputation. This process occurs through the formation of a wound epithelium and the dedifferentiation of mesenchymal and bone‐forming cells, which form a proliferative blastema. Here, we report that the entry into the regenerative process...

Université de Fribourg

Zebrafish fin regeneration after cryoinjury-induced tissue damage

Chassot, Bérénice ; Pury, David ; Jaźwińska, Anna

In: Biology Open, 2016, vol. 5, no. 6, p. 819–828

Although fin regeneration following an amputation procedure has been well characterized, little is known about the impact of prolonged tissue damage on the execution of the regenerative programme in the zebrafish appendages. To induce histolytic processes in the caudal fin, we developed a new cryolesion model that combines the detrimental effects of freezing/thawing and ischemia. In contrast...

Université de Fribourg

Zebrafish caudal fin angiogenesis assay—advanced quantitative assessment including 3-way correlative microscopy

Hlushchuk, Ruslan ; Brönnimann, Daniel ; Shokiche, Carlos Correa ; Schaad, Laura ; Triet, Ramona ; Jazwinska, Anna ; Tschanz, Stefan A. ; Djonov, Valentin

In: PLOS ONE, 2016, vol. 11, no. 3, p. e0149281

Background: Researchers evaluating angiomodulating compounds as a part of scientific projects or pre-clinical studies are often confronted with limitations of applied animal models. The rough and insufficient early-stage compound assessment without reliable quantification of the vascular response counts, at least partially, to the low transition rate to clinics. Objective: To establish an...

Université de Fribourg

Zamolodchikov–Faddeev algebra and quantum quenches in integrable field theories

Sotiriadis, S. ; Fioretto, Davide ; Mussardo, G.

In: Journal of Statistical Mechanics: Theory and Experiment, 2012, no. 2, p. P02017

We analyze quantum quenches in integrable models and in particular we determine the initial state in the basis of eigenstates of the post-quench Hamiltonian. This leads us to consider the set of transformations of creation and annihilation operators that respect the Zamolodchikov–Faddeev algebra satisfied by integrable models. We establish that the Bogoliubov transformations hold only in the...

Université de Fribourg

Ypk1/Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodelling after membrane stresses

Hatakeyama, Riko ; Kono, Keiko ; Yoshida, Satoshi

In: J Cell Sci, 2017, p. jcs.198382

The plasma membrane (PM) is frequently challenged by mechanical stresses. In budding yeast, TORC2-Ypk1/Ypk2 kinase cascade plays a critical role in PM stress responses by reorganizing the actin cytoskeleton via Rho1 GTPase. However, the molecular mechanism by which TORC2-Ypk1/Ypk2 regulates Rho1 is not well defined. Here, we found that Ypk1/Ypk2 maintain PM localization of Rho1 under PM...

Université de Fribourg

Ypk1, the yeast orthologue of the human serum- and glucocorticoid-induced kinase, is required for efficient uptake of fatty acids

Jacquier, Nicolas ; Schneiter, Roger

In: Journal of Cell Science, 2010, vol. 123, p. 2218-2227

Fatty acids constitute an important energy source for various tissues. The mechanisms that mediate and control uptake of free fatty acids from the circulation, however, are poorly understood. Here we show that efficient fatty-acid uptake by yeast cells requires the protein kinase Ypk1, the orthologue of the human serum- and glucocorticoid-induced kinase Sgk1. ypk1δ mutant cells fail to...