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Université de Fribourg

Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue

Duteil, Delphine ; Tosic, Milica ; Lausecker, Franziska ; Nenseth, Hatice Z. ; Müller, Judith M. ; Urban, Sylvia ; Willmann, Dominica ; Petroll, Kerstin ; Messaddeq, Nadia ; Arrigoni, Laura ; Manke, Thomas ; Kornfeld, Jan-Wilhelm ; Brüning, Jens C. ; Zagoriy, Vyacheslav ; Meret, Michael ; Dengjel, Jörn ; Kanouni, Toufike ; Schüle, Roland

In: Cell Reports, 2016, vol. 17, no. 4, p. 1008–1021

Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT- selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. This shift is associated with downregulation of BAT-specific and...

Université de Fribourg

Pathways from dieting to weight regain, to obesity and to the metabolic syndrome: an overview

Dulloo, Abdull G. ; Montani, Jean-Pierre

In: Obesity Reviews, 2015, vol. 16, p. 1–6

Every year, scores of millions of people – as diverse as obese and lean, teenagers and older adults, sedentary and elite athletes, commoners and celebrities – attempt to lose weight on some form of diet. They are often encouraged by their parents, friends, health professionals, training coaches, a media that promotes a slim image and a diet-industry that in Europe and United States alone has...

Université de Fribourg

Dieting and weight cycling as risk factors for cardiometabolic diseases: who is really at risk?

Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: Obesity Reviews, 2015, vol. 16, p. 7–18

Despite the poor prognosis of dieting in obesity management, which often results in repeated attempts at weight loss and hence weight cycling, the prevalence of dieting has increased continuously in the past decades in parallel to the steadily increasing prevalence of obesity. However, dieting and weight cycling are not limited to those who are obese or overweight as substantial proportions of...

Université de Fribourg

Translational issues in targeting brown adipose tissue thermogenesis for human obesity management

Dulloo, Abdul G.

In: Annals of the New York Academy of Sciences, 2013, vol. 1302, no. 1, p. 1–10

The recent advancements in unraveling novel mechanisms that control the induction, (trans)differentiation, proliferation, and thermogenic activity and capacity of brown adipose tissue (BAT), together with the application of imaging techniques for human BAT visualization, have generated optimism that these advances will provide novel strategies for targeting BAT thermogenesis, leading to...

Université de Fribourg

Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors

Wymann, Matthias P. ; Solinas, Giovanni

In: Annals of the New York Academy of Sciences, 2013, vol. 1280, p. 44-47

Phosphoinositide 3-kinase γ (PI3Kγ) plays a central role in inflammation, allergy, cardiovascular, and metabolic disease. Obesity is accompanied by chronic, low-grade inflammation. As PI3Kγ plays a major role in leukocyte recruitment, targeting of PI3Kγ has been considered to be a strategy for attenuating progression of obesity to insulin resistance and type 2 diabetes. Indeed, PI3Kγ null...

Université de Fribourg

mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases

Yang, Zhihong ; Ming, Xiu-Fen

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 58–68

The continuing increase in the prevalence of obesity and metabolic disorders such as type-II diabetes and an accelerating aging population globally will remain the major contributors to cardiovascular mortality and morbidity in the 21st century. It is well known that aging is highly associated with metabolic and cardiovascular diseases. Growing evidence also shows that obesity and metabolic...

Université de Fribourg

Adaptive thermogenesis in human body weight regulation: more of a concept than a measurable entity?

Dulloo, Abdul G. ; Jacquet, Jean ; Montani, Jean-Pierre ; Schutz, Yves

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 105–121

According to Lavoisier, ‘Life is combustion’. But to what extent humans adapt to changes in food intake through adaptive thermogenesis – by turning down the rate of heat production during energy deficit (so as to conserve energy) or turning it up during overnutrition (so as to dissipate excess calories) – has been one of the most controversial issues in nutritional sciences over the past...

Université de Fribourg

The search for compounds that stimulate thermogenesis in obesity management: from pharmaceuticals to functional food ingredients

Dulloo, Abdull G.

In: Obesity Reviews, 2011, vol. 12, no. 10, p. 866–883

The concept of managing obesity through the stimulation of thermogenesis is currently a focus of considerable attention by the pharmaceutical, nutraceutical and functional food industries. This paper first reviews the landmark discoveries that have fuelled the search for thermogenic anti-obesity products that range from single-target drugs to multi-target functional foods. It subsequently...