Université de Fribourg

Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue

Duteil, Delphine ; Tosic, Milica ; Lausecker, Franziska ; Nenseth, Hatice Z. ; Müller, Judith M. ; Urban, Sylvia ; Willmann, Dominica ; Petroll, Kerstin ; Messaddeq, Nadia ; Arrigoni, Laura ; Manke, Thomas ; Kornfeld, Jan-Wilhelm ; Brüning, Jens C. ; Zagoriy, Vyacheslav ; Meret, Michael ; Dengjel, Jörn ; Kanouni, Toufike ; Schüle, Roland

In: Cell Reports, 2016, vol. 17, no. 4, p. 1008–1021

Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT- selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. This shift is associated with downregulation of BAT-specific and...