Université de Fribourg

Impairment of acquisition of intravenous cocaine self-administration by RNA-interference of dopamine D1-receptors in the nucleus accumbens shell

Pisanu, Augusta ; Lecca, Daniele ; Valentini, Valentina ; Bahi, Amine ; Dreyer, Jean-Luc ; Cacciapaglia, Fabio ; Scifo, Andrea ; Piras, Giovanna ; Cadoni, Cristina ; Chiara, Gaetano Di

In: Neuropharmacology, 2015, vol. 89, p. 398–411

Microdialysis during i.v. drug self-administration (SA) have implicated nucleus accumbens (NAc) shell DA in cocaine and heroin reinforcement. However, this correlative evidence has not been yet substantiated by experimental evidence obtained by studying the effect of selective manipulation of NAc shell DA transmission on cocaine and heroin SA. In order to investigate this issue, DA D1a receptor...

Université de Fribourg

The brain-specific Neural Zinc Finger transcription factor 2b (NZF-2b/7ZFMyt1) causes suppression of cocaine-induced locomotor activity

Chandrasekar, Vijay ; Dreyer, Jean-Luc

In: Neurobiology of Disease, 2009, vol. 37, no. 1, p. 86-98

Chronic cocaine induces high expression of the brain-specific Neural-Zinc-Finger transcription factor-2b (NZF-2b/7ZFMyt1), particularly in the mesolimbic dopaminergic pathway, resulting in a 11-fold increase in NZF-2b/7ZFMyt1 expression in the Nucleus Accumbens (NAc). Overexpression of this gene in the NAc with a NZF-2b/7ZFMyt1-expressing lentivirus resulted in >55% decrease in locomotor activity...