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Université de Fribourg

Parvalbumin-expressing ependymal cells in rostral lateral ventricle wall adhesions contribute to aging-related ventricle stenosis in mice

Filice, Federica ; Celio, Marco R. ; Babalian, Alexandre ; Blum, Walter ; Szabolcsi, Viktoria

In: Journal of Comparative Neurology, 2017, vol. 525, no. 15, p. 3266–3285

Aging-associated ependymal-cell pathologies can manifest as ventricular gliosis, ventricle enlargement, or ventricle stenosis. Ventricle stenosis and fusion of the lateral ventricle (LV) walls is associated with a massive decline of the proliferative capacities of the stem cell niche in the affected subventricular zone (SVZ) in aging mice. We examined the brains of adult C57BL/6 mice and...

Université de Fribourg

Aging causes a reorganization of cortical and spinal control of posture

Papegaaij, Selma ; Taube, Wolfgang ; Baudry, Stéphane ; Otten, Egbert ; Hortobágyi, Tibor

In: Frontiers in Aging Neuroscience, 2014, vol. 6, p. 28

Classical studies in animal preparations suggest a strong role for spinal control of posture. In humans it is now established that the cerebral cortex contributes to postural control of unperturbed and perturbed standing. The age-related degeneration and accompanying functional changes in the brain, reported so far mainly in conjunction with simple manual motor tasks, may also affect the...

Université de Fribourg

The Caenorhabditis elegans LET-418/Mi2 plays a conserved role in lifespan regulation

Vaux, Véronique De ; Pfefferli, Catherine ; Passannante, Myriam ; Belhaj, Khaoula ; Essen, Alina von ; Sprecher, Simon G. ; Müller, Fritz ; Wicky, Chantal

In: Aging Cell, 2013, p. –

The evolutionarily conserved nucleosome-remodeling protein Mi2 is involved in transcriptional repression during development in various model systems, plays a role in embryonic patterning and germ line development, and participates in DNA repair and cell cycle progression. It is the catalytic subunit of the nucleosome remodeling and histone deacetylase (NuRD) complex, a key determinant of...

Université de Fribourg

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

Yepuri, Gautham ; Velagapudi, Srividya ; Xiong, Yuyan ; Rajapakse, Angana G. ; Montani, Jean-Pierre ; Ming, Xiu-Fen ; Yang, Zhihong

In: Aging Cell, 2012, p. -

Augmented activities of both arginase and S6K1 are involved in endothelial dysfunction in aging. This study was to investigate whether or not there is a crosstalk between arginase and S6K1 in endothelial inflammation and aging in senescent human umbilical vein endothelial cells and in aging mouse models. We show increased arginase-II (Arg-II) expression/activity in senescent endothelial cells....

Université de Fribourg

Perspectives of targeting mTORC1–S6K1 in cardiovascular aging

Ming, Xiu-Fen ; Montani, Jean-Pierre ; Yang, Zhihong

In: Frontiers in Vascular Physiology, 2012, vol. 3, p. 5

The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging. The underlying mechanisms of aging and age-associated cardiovascular dysfunction remain elusive. There are substantial evidences demonstrating a pivotal role of the mammalian target of rapamycin complex 1 (mTORC1) and its down-stream effector S6K1 signaling in...

Université de Fribourg

The absence of the calcium-buffering protein calbindin is associated with faster age-related decline in hippocampal metabolism

Moreno, Herman ; Burghardt, Nesha S. ; Vela-Duarte, Daniel ; Masciotti, James ; Hua, Fan ; Fenton, André A. ; Schwaller, Beat ; Small, Scott A.

In: Hippocampus, 2012, vol. 22, p. 1107-1120

Although reductions in the expression of the calcium-buffering proteins calbindin D-28K (CB) and parvalbumin (PV) have been observed in the aging brain, it is unknown whether these changes contribute to age-related hippocampal dysfunction. To address this issue, we measured basal hippocampal metabolism and hippocampal structure across the lifespan of C57BL/6J, calbindin D-28k knockout (CBKO) and...

Université de Fribourg

Orchestration of gene expression and physiology by the circadian clock

Albrecht, Urs

In: Journal of Physiology-Paris, 2006, vol. 100, no. 5-6, p. 243-251

In mammals, the master circadian clock that drives many biochemical, physiological and behavioral rhythms is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. Generation and maintenance of circadian rhythms rely on complex interlaced feedback loops based on transcriptional and posttranscriptional events involving clock genes and kinases. This clock serves the purpose to organize an...

Université de Fribourg

Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster

Flatt, Thomas ; Kawecki, Tadeusz J.

In: Evolution, 2007, vol. 61, no. 8, p. 1980–1991

Trade-offs between reproduction and life span are ubiquitous, but little is known about their underlying mechanisms. Here we combine treatment with the juvenile hormone analog (JHa) methoprene and experimental evolution in Drosophila melanogaster to study the potential role of juvenile hormone (JH) in mediating such trade-offs at both the physiological and evolutionary level. Exposure to...

Université de Fribourg

Life time—circadian clocks, mitochondria and metabolism

Langmesser, Sonja ; Albrecht, Urs

In: Chronobiology International, 2006, vol. 23, no. 1-2, p. 51–157

A functional circadian clock has long been considered a selective advantage. Accumulating evidence shows that the clock coordinates a variety of physiological processes in order to schedule them to the optimal time of day and thus to synchronize metabolism to changes in external conditions. In mitochondria, both metabolic and cellular defense mechanisms are carefully regulated. Abnormal clock...

Université de Fribourg

A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions

Jud, Corinne ; Schmutz, Isabelle ; Hampp, Gabriele ; Oster, Henrik ; Albrecht, Urs

In: Biological Procedures Online 2005, 7(1)/101-116/

Most behavioral experiments within circadian research are based on the analysis of locomotor activity. This paper introduces scientists to chronobiology by explaining the basic terminology used within the field. Furthermore, it aims to assist in designing, carrying out, and evaluating wheel-running experiments with rodents, particularly mice. Since light is an easily applicable stimulus that...