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Université de Fribourg

Schistosoma mansoni venom allergen-like protein 4 (SmVAL4) is a novel lipid-binding SCP/TAPS protein that lacks the prototypical CAP motifs

Kelleher, Allan ; Darwiche, Rabih ; Rezende, Wanderson C. ; Farias, Leonardo P. ; Leite, Luciana C. C. ; Schneiter, Roger ; Asojo, Oluwatoyin A.

In: Acta Crystallographica Section D Biological Crystallography, 2014, vol. 70, no. 8, p. 2186–2196

Schistosomiasis is a parasitic disease that affects over 200 million people. Vaccine candidates have been identified, including Schistosoma mansoni venom allergen- like proteins (SmVALs) from the SCP/TAPS (sperm-coating protein/Tpx/antigen 5/pathogenesis related-1/Sc7) superfamily. The first SmVAL structure, SmVAL4, was refined to a resolution limit of 2.16 Å. SmVAL4 has a unique...