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Université de Fribourg

Structure and development of the subesophageal zone of the Drosophila brain. II. Sensory compartments

Kendroud, Sarah ; Bohra, Ali A. ; Kuert, Philipp A. ; Nguyen, Bao ; Guillermin, Oriane ; Sprecher, Simon G. ; Reichert, Heinrich ; VijayRaghavan, Krishnaswamy ; Hartenstein, Volker

In: Journal of Comparative Neurology, 2018, vol. 526, no. 1, p. 33–58

The subesophageal zone (SEZ) of the Drosophila brain processes mechanosensory and gustatory sensory input from sensilla located on the head, mouth cavity and trunk. Motor output from the SEZ directly controls the movements involved in feeding behavior. In an accompanying paper (Hartenstein et al., 2017), we analyzed the systems of fiber tracts and secondary lineages to establish reliable...

Université de Fribourg

Plasticity in the Drosophila larval visual system

Farca-Luna, Abud J. ; Sprecher, Simon G.

In: Frontiers in Cellular Neuroscience, 2013, vol. 7, p. 105

The remarkable ability of the nervous system to modify its structure and function is mostly experience and activity modulated. The molecular basis of neuronal plasticity has been studied in higher behavioral processes, such as learning and memory formation. However, neuronal plasticity is not restricted to higher brain functions and it may provide a basic feature of adaptation of all neural...

Université de Fribourg

Analysis of cell identity, morphology, apoptosis and mitotic activity in a primary neural cell culture system in Drosophila

Moraru, Manuela M ; Egger, Boris ; Bao, Diarra B. ; Sprecher, Simon G.

In: Neural Development, 2012, vol. 7, p. 14

In Drosophila, most neurogenetic research is carried out in vivo. Mammalian research demonstrates that primary cell culture techniques provide a powerful model to address cell autonomous and non-autonomous processes outside their endogenous environment. We developed a cell culture system in Drosophila using wildtype and genetically manipulated primary neural tissue for long-term observations. We...

Université de Fribourg

Diversity, variability, and suboesophageal connectivity of antennal lobe neurons in D. melanogaster larvae

Thum, Andreas S. ; Leisibach, Basil ; Gendre, Nanaë ; Selcho, Mareike ; Stocker, Reinhard F.

In: The Journal of Comparative Neurology, 2011, vol. 59, no. 17, p. 3415–3432

Whereas the “vertical” elements of the insect olfactory pathway, the olfactory receptor neurons and the projection neurons, have been studied in great detail, local interneurons providing “horizontal” connections in the antennal lobe were ignored for a long time. Recent studies in adult Drosophila demonstrate diverse roles for these neurons in the integration of odor information,...

Université de Fribourg

The Drosophila larval visual system: High-resolution analysis of a simple visual neuropil

Sprecher, Simon G. ; Cardona, Albert ; Hartenstein, Volker

In: Developmental Biology, 2011, p. -

The task of the visual system is to translate light into neuronal encoded information. This translation of photons into neuronal signals is achieved by photoreceptor neurons (PRs), specialized sensory neurons, located in the eye. Upon perception of light the PRs will send a signal to target neurons, which represent a first station of visual processing. Increasing complexity of visual processing...

Université de Fribourg

The olfactory pathway of adult and larval Drosophila: conservation or adaptation to stage-specific needs ?

Stocker, Reinhard F.

In: Annals of the New York Academy of Sciences, 2009, vol. 1170, p. 482 - 486

Tracing of olfactory projections based on odorant receptor expression has led to an almost complete receptor-to-glomerulus map in adult Drosophila. While most of the glomeruli may be involved in processing of food odors, others appear to be more specialized, for example, responding to CO₂ or to pheromonal cues. Recent studies have shed light on signal processing in the antennal lobe and in...

Université de Fribourg

Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster

Flatt, Thomas ; Kawecki, Tadeusz J.

In: Evolution, 2007, vol. 61, no. 8, p. 1980–1991

Trade-offs between reproduction and life span are ubiquitous, but little is known about their underlying mechanisms. Here we combine treatment with the juvenile hormone analog (JHa) methoprene and experimental evolution in Drosophila melanogaster to study the potential role of juvenile hormone (JH) in mediating such trade-offs at both the physiological and evolutionary level. Exposure to...