Université de Fribourg

Rivastigmine for HIV-associated neurocognitive disorders A randomized crossover pilot study

Simioni, Samanta ; Cavassini, Matthias ; Annoni, Jean-Marie ; Iglesias, Mélanie Métral, Katia ; Abraham, Aline Rimbault ; Jilek, Samantha ; Calmy, Alexandra ; Müller, Hubertus ; Fayet-Mello, Aurélie ; Giacobini, Ezio ; Hirschel, Bernard ; Pasquier, Renaud A. Du

In: Neurology, 2013, vol. 80, no. 6, p. 553–560

Objective: To assess the efficacy and safety of rivastigmine for the treatment of HIV-associated neurocognitive disorders (HAND) in a cohort of long-lasting aviremic HIV+ patients.Methods: Seventeen aviremic HIV+ patients with HAND were enrolled in a randomized, double-blind, placebo-controlled, crossover study to receive either oral rivastigmine (up to 12 mg/day for 20 weeks) followed by placebo...