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characteristics of rod regeneration in a novel zebrafish retinal degeneration model using N-methyl-N-nitrosourea (MNU)

Tappeiner, Christoph ; Balmer, Jasmin ; Iglicki, Matias ; Schuerch, Kaspar ; Jazwinska, Anna ; Enzmann, Volker ; Tschopp, Markus

In: PLoS ONE, 2013, vol. 8, no. 8, p. e71064

Primary loss of photoreceptors caused by diseases such as retinitis pigmentosa is one of the main causes of blindness worldwide. To study such diseases, rodent models of N-methyl-N-nitrosourea (MNU)-induced retinal degeneration are widely used. As zebrafish (Danio rerio) are a popular model system for visual research that offers persistent retinal neurogenesis throughout the lifetime and retinal...