In: Brain Structure and Function, 2015, vol. 220, no. 4, p. 2121-2142
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In: Journal of Neuroscience, 2018, vol. 38, no. 50, p. 10644–10656
A restricted lesion of the hand area in the primary motor cortex (M1) leads to a deficit of contralesional manual dexterity, followed by an incomplete functional recovery, accompanied by plastic changes in M1 itself and in other cortical areas on both hemispheres. Using the marker SMI-32 specific to pyramidal neurons in cortical layers III and V, we investigated the impact of a focal...
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In: Brain Structure and Function, 2015, vol. 220, no. 4, p. 2121–2142
High-density scalp EEG recordings are widely used to study whole-brain neuronal networks in humans non-invasively. Here, we validate EEG mapping of somatosensory evoked potentials (SSEPs) in macaque monkeys (Macaca fascicularis) for the long-term investigation of large-scale neuronal networks and their reorganisation after lesions requiring a craniotomy. SSEPs were acquired from 33 scalp...
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In: médecine/sciences, 2015, vol. 31, no. 4, p. 363–366
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In: Current Biology, 2015, vol. 25, no. 1, p. 109–116
Cortical activity allotted to the tactile receptors on fingertips conforms to skilful use of the hand [1, 2 and 3]. For instance, in string instrument players, the somatosensory cortical activity in response to touch on the little fingertip is larger than that in control subjects [1]. Such plasticity of the fingertip sensory representation is not limited to extraordinary skills and occurs in...
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In: Brain and Behavior, 2013, vol. 3, no. 5, p. 575–595
The present study aimed to determine and confront hand preference (hand chosen in priority to perform a manual dexterity task) and hand dominance (hand with best motor performance) in eight macaques (Macaca fascicularis) and in 20 human subjects (10 left-handers and 10 right-handers).Methods: Four manual dexterity tests have been executed by the monkeys, over several weeks during learning and...
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In: Journal of Biomedical Optics, 2011, vol. 16, no. 09, p. 096011
The nonhuman primate model is suitable to study mechanisms of functional recovery following lesion of the cerebral cortex (motor cortex), on which therapeutic strategies can be tested. To interpret behavioral data (time course and extent of functional recovery), it is crucial to monitor the properties of the experimental cortical lesion, induced by infusion of the excitotoxin ibotenic acid. In...
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