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Université de Fribourg

Parvalbumin-expressing ependymal cells in rostral lateral ventricle wall adhesions contribute to aging-related ventricle stenosis in mice

Filice, Federica ; Celio, Marco R. ; Babalian, Alexandre ; Blum, Walter ; Szabolcsi, Viktoria

In: Journal of Comparative Neurology, 2017, vol. 525, no. 15, p. 3266–3285

Aging-associated ependymal-cell pathologies can manifest as ventricular gliosis, ventricle enlargement, or ventricle stenosis. Ventricle stenosis and fusion of the lateral ventricle (LV) walls is associated with a massive decline of the proliferative capacities of the stem cell niche in the affected subventricular zone (SVZ) in aging mice. We examined the brains of adult C57BL/6 mice and...

Université de Fribourg

The role of parvalbumin and calbindin D28k in experimental scrapie

Voigtländer, T. ; Unterberger, U. ; Guentchev, M. ; Schwaller, Beat ; Celio, Marco R. ; Meyer, M. ; Budka, H.

In: Neuropathology and Applied Neurobiology, 2008, vol. 34, no. 4, p. 435 - 445

Aims: Prion diseases are generally characterized by pronounced neuronal loss. In particular, a subpopulation of inhibitory neurones, characterized by the expression of the calcium-binding protein parvalbumin (PV), is selectively destroyed early in the course of human and experimental prion diseases. By contrast, nerve cells expressing calbindin D28k (CB), another calcium-binding protein, as well...