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Overexpression or absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration

Blum, Walter ; Pecze, László ; Felley-Bosc, Emanuela

In: Respiratory Research, 2015, vol. 16, p. 153

The Ca2+-binding protein calretinin is currently used as a positive marker for identifying epithelioid malignant mesothelioma (MM) and reactive mesothelium, but calretinin’s likely role in mesotheliomagenesis remains unclear. Calretinin protects immortalized mesothelial cells in vitro from asbestos-induced cytotoxicity and thus might be implicated in mesothelioma formation. To further...