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Université de Fribourg

Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbumin, calbindin D-28k or both

Farré-Castany, Maria A. ; Schwaller, Beat ; Gregory, Patrick ; Barski, Jaroslaw ; Mariethoz, Céline ; Eriksson, Jan L. ; Tetko, Igor V. ; Wolfer, David ; Celio, Marco R. ; Schmutz, Isabelle ; Albrecht, Urs ; Villa, Alessandro E.P.

In: Behavioural Brain Research, 2007, vol. 178, no. 2, p. 250-261

We investigated the role of the two calcium-binding proteins parvalbumin (PV) and calbindin D-28k (CB) in the locomotor activity and motor coordination using null-mutant mice for PV (PV−/−), CB (CB−/−) or both proteins (PV−/−CB−/−). These proteins are expressed in distinct, mainly non-overlapping populations of neurons of the central and peripheral nervous system and PV...

Université de Fribourg

Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones

Schmidt, Hartmut ; Arendt, Oliver ; Brown, Edward B. ; Schwaller, Beat ; Eilers, Jens

In: Journal of Neurochemistry, 2007, vol. 100, no. 3, p. 727–735

The Ca²⁺-binding protein (CaBP) parvalbumin (PV) is strongly expressed in cerebellar Purkinje neurones (PNs). It is considered a pure Ca²⁺ buffer, lacking any Ca²⁺ sensor function. Consistent with this notion, no PV ligand was found in dendrites of PNs. Recently, however, we observed for a related CaBP that ligand-targeting differs substantially between dendrites and axons. Thus, here we...

Université de Fribourg

Deficiency in parvalbumin, but not in calbindin D-28k upregulates mitochondrial volume and decreases smooth endoplasmic reticulum surface selectively in a peripheral, subplasmalemmal region in the soma of Purkinje cells

Chen, G. ; Racay, Peter ; Bichet, S. ; Celio, Marco R. ; Eggli, P. ; Schwaller, Beat

In: Neuroscience, 2006, vol. 142, no. 1, p. 97-105

The Ca²⁺-binding proteins parvalbumin (PV) and calbindin D-28k (CB) are key players in the intracellular Ca²⁺-buffering in specific cells including neurons and have profound effects on spatiotemporal aspects of Ca²⁺ transients. The previously observed increase in mitochondrial volume density in fast-twitch muscle of PV−/− mice is viewed as a specific compensation mechanism to...

Université de Fribourg

Ectopic parvalbumin expression in mouse forebrain neurons increases excitotoxic injury provoked by ibotenic acid injection into the striatum

Maetzler, Walter ; Bendfeldt, Kerstin ; Racay, Peter ; Vollenweider, Florence ; Schwaller, Beat

In: Experimental Neurology, 2004, vol. 186(1), p. 78

A neuroprotective role for Ca²⁺-binding proteins in neurodegenerative conditions ranging from ischemia to Alzheimer's disease has been suggested in several studies. A key phenomenon in neurodegeneration is the Ca²⁺-mediated excitotoxicity brought about by the neurotransmitter glutamate. To evaluate the relative ability to resist excitotoxicity of neurons containing the slow-onset...

Université de Fribourg

Over-expression of parvalbumin in transgenic mice rescues motoneurons from injury-induced cell death

Dekkers, J. ; Bayley, P. ; Dick, J. R. T. ; Schwaller, Beat ; Berchtold, M. W. ; Greensmith, L.

In: Neuroscience, 2004, vol. 123(2), p. 459-466

Following nerve injury in neonatal rats, a large proportion of motoneurons die, possibly as a consequence of an increase in vulnerability to the excitotoxic effects of glutamate. Calcium-dependent glutamate excitotoxicity is thought to play a significant role not only in injury-induced motoneuron death, but also in motoneuron degeneration in diseases such as amyotrophic lateral sclerosis (ALS)....

Université de Fribourg

Rapid turnover of the “functional” Na⁺–Ca²⁺ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach

Egger, Marcel ; Porzig, Hartmut ; Niggli, Ernst ; Schwaller, Beat

In: Cell Calcium, 2005, vol. 37(3), p. 233

Antisense oligodeoxynucleotides (AS-ODNs) were used in combination with transient functional expression of the cardiac Na⁺–Ca²⁺ exchanger (NCX1) to correlate suppression of the Na⁺–Ca²⁺ exchange function with down-regulation of NCX1 protein expression. In a de-novo expression system (Sf9 cells), a decrease in both, NCX1 mRNA and protein after AS-ODN application was paralleled by...

Université de Fribourg

Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures

Schwaller, Beat ; Tetko, I. V. ; Tandon, P. ; Silveira, D. C. ; Vreugdenhil, M. ; Henzi, Thomas ; Potier, M. -C. ; Celio, Marco R. ; Villa, A. E. P.

In: Molecular and Cellular Neuroscience, 2004, vol. 24(4), p. 650

Networks of GABAergic interneurons are of utmost importance in generating and promoting synchronous activity and are involved in producing coherent oscillations. These neurons are characterized by their fast-spiking rate and by the expression of the Ca²⁺-binding protein parvalbumin (PV). Alteration of their inhibitory activity has been proposed as a major mechanism leading to epileptic...

Université de Fribourg

Developmental changes in Parvalbumin regulate presynaptic Ca²⁺ signaling

Collin, Thibault ; Chat, Mireille ; Lucas, Marie Gabrielle ; Moreno, Herman ; Racay, Peter ; Schwaller, Beat ; Marty, Alain ; Llano, Isabel

In: The Journal of Neuroscience, 2005, vol. 25(1), p. 96

Certain interneurons contain large concentrations of specific Ca²⁺-binding proteins (CBPs), but consequences on presynaptic Ca²⁺ signaling are poorly understood. Here we show that expression of the slow CBP parvalbumin (PV) in cerebellar interneurons is cell specific and developmentally regulated, leading to characteristic changes in presynaptic Ca²⁺ dynamics (Cai). Using...

Université de Fribourg

Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures

Schwaller, Beat ; Tetko, I. V. ; Tandon, P. ; Silveira, D. C. ; Vreugdenhil, M. ; Henzi, Thomas ; Potier, M. -C. ; Celio, Marco R. ; Villa, A. E. P.

In: Molecular and Cellular Neuroscience, 2004, vol. 25(4), p. 650-663

Networks of GABAergic interneurons are of utmost importance in generating and promoting synchronous activity and are involved in producing coherent oscillations. These neurons are characterized by their fast-spiking rate and by the expression of the Ca2+-binding protein parvalbumin (PV). Alteration of their inhibitory activity has been proposed as a major mechanism leading to epileptic seizures...