Université de Fribourg

Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones

Schmidt, Hartmut ; Arendt, Oliver ; Brown, Edward B. ; Schwaller, Beat ; Eilers, Jens

In: Journal of Neurochemistry, 2007, vol. 100, no. 3, p. 727–735

The Ca²⁺-binding protein (CaBP) parvalbumin (PV) is strongly expressed in cerebellar Purkinje neurones (PNs). It is considered a pure Ca²⁺ buffer, lacking any Ca²⁺ sensor function. Consistent with this notion, no PV ligand was found in dendrites of PNs. Recently, however, we observed for a related CaBP that ligand-targeting differs substantially between dendrites and axons. Thus, here we...

Université de Fribourg

Developmental changes in Parvalbumin regulate presynaptic Ca²⁺ signaling

Collin, Thibault ; Chat, Mireille ; Lucas, Marie Gabrielle ; Moreno, Herman ; Racay, Peter ; Schwaller, Beat ; Marty, Alain ; Llano, Isabel

In: The Journal of Neuroscience, 2005, vol. 25(1), p. 96

Certain interneurons contain large concentrations of specific Ca²⁺-binding proteins (CBPs), but consequences on presynaptic Ca²⁺ signaling are poorly understood. Here we show that expression of the slow CBP parvalbumin (PV) in cerebellar interneurons is cell specific and developmentally regulated, leading to characteristic changes in presynaptic Ca²⁺ dynamics (Cai). Using...