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Université de Fribourg

Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones

Schmidt, Hartmut ; Arendt, Oliver ; Brown, Edward B. ; Schwaller, Beat ; Eilers, Jens

In: Journal of Neurochemistry, 2007, vol. 100, no. 3, p. 727–735

The Ca²⁺-binding protein (CaBP) parvalbumin (PV) is strongly expressed in cerebellar Purkinje neurones (PNs). It is considered a pure Ca²⁺ buffer, lacking any Ca²⁺ sensor function. Consistent with this notion, no PV ligand was found in dendrites of PNs. Recently, however, we observed for a related CaBP that ligand-targeting differs substantially between dendrites and axons. Thus, here we...