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Université de Fribourg

Developmental changes in Parvalbumin regulate presynaptic Ca²⁺ signaling

Collin, Thibault ; Chat, Mireille ; Lucas, Marie Gabrielle ; Moreno, Herman ; Racay, Peter ; Schwaller, Beat ; Marty, Alain ; Llano, Isabel

In: The Journal of Neuroscience, 2005, vol. 25(1), p. 96

Certain interneurons contain large concentrations of specific Ca²⁺-binding proteins (CBPs), but consequences on presynaptic Ca²⁺ signaling are poorly understood. Here we show that expression of the slow CBP parvalbumin (PV) in cerebellar interneurons is cell specific and developmentally regulated, leading to characteristic changes in presynaptic Ca²⁺ dynamics (Cai). Using...