Université de Fribourg

Parvalbumin: calcium and magnesium buffering in the distal nephron

Olinger, Eric ; Schwaller, Beat ; Loffing, Johannes ; Gailly, Philippe ; Devuys, Olivier

In: Nephrology Dialysis Transplantation, 2012, vol. 27, no. 11, p. 3988-3994

Parvalbumin (PV) is a classical member of the EF-hand protein superfamily that has been described as a Ca²⁺ buffer and Ca²⁺ transporter/shuttle protein and may also play an additional role in Mg²⁺ handling. PV is exclusively expressed in the early part of the distal convoluted tubule in the human and mouse kidneys. Recent studies in Pvalb knockout mice revealed a role of PV in...