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The use of transgenic mouse models to reveal the functions of Ca² ⁺ buffer proteins in excitable cells

Schwaller, Beat

In: Biochimica et Biophysica Acta (BBA) - General Subjects, 2012, p. -

Background Cytosolic Ca² ⁺ buffers are members of the large family of Ca² ⁺-binding proteins and are essential components of the Ca² ⁺ signaling toolkit implicated in the precise regulation of intracellular Ca² ⁺ signals. Their physiological role in excitable cells has been investigated in vivo by analyzing the phenotype of mice either lacking one of the Ca² ⁺ buffers or...

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Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbumin, calbindin D-28k or both

Farré-Castany, Maria A. ; Schwaller, Beat ; Gregory, Patrick ; Barski, Jaroslaw ; Mariethoz, Céline ; Eriksson, Jan L. ; Tetko, Igor V. ; Wolfer, David ; Celio, Marco R. ; Schmutz, Isabelle ; Albrecht, Urs ; Villa, Alessandro E.P.

In: Behavioural Brain Research, 2007, vol. 178, no. 2, p. 250-261

We investigated the role of the two calcium-binding proteins parvalbumin (PV) and calbindin D-28k (CB) in the locomotor activity and motor coordination using null-mutant mice for PV (PV−/−), CB (CB−/−) or both proteins (PV−/−CB−/−). These proteins are expressed in distinct, mainly non-overlapping populations of neurons of the central and peripheral nervous system and PV...

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