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Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

Filice, Federica ; Vörckel, Karl Jakob ; Sungur, Ayse Özge ; Wöhr, Markus ; Schwaller, Beat

In: Molecular Brain, 2016, vol. 9, p. 10

Background A reduction of the number of parvalbumin (PV)-immunoreactive (PV⁺) GABAergic interneurons or a decrease in PV immunoreactivity was reported in several mouse models of autism spectrum disorders (ASD). This includes Shank mutant mice, with SHANK being one of the most important gene families mutated in human ASD. Similar findings were obtained in heterozygous (PV+/-)...

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The use of transgenic mouse models to reveal the functions of Ca² ⁺ buffer proteins in excitable cells

Schwaller, Beat

In: Biochimica et Biophysica Acta (BBA) - General Subjects, 2012, p. -

Background Cytosolic Ca² ⁺ buffers are members of the large family of Ca² ⁺-binding proteins and are essential components of the Ca² ⁺ signaling toolkit implicated in the precise regulation of intracellular Ca² ⁺ signals. Their physiological role in excitable cells has been investigated in vivo by analyzing the phenotype of mice either lacking one of the Ca² ⁺ buffers or...

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