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The use of transgenic mouse models to reveal the functions of Ca² ⁺ buffer proteins in excitable cells

Schwaller, Beat

In: Biochimica et Biophysica Acta (BBA) - General Subjects, 2012, p. -

Background Cytosolic Ca² ⁺ buffers are members of the large family of Ca² ⁺-binding proteins and are essential components of the Ca² ⁺ signaling toolkit implicated in the precise regulation of intracellular Ca² ⁺ signals. Their physiological role in excitable cells has been investigated in vivo by analyzing the phenotype of mice either lacking one of the Ca² ⁺ buffers or...