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    Université de Fribourg

    Dysregulation of parvalbumin expression in the Cntnap2−/− mouse model of autism spectrum disorder

    Lauber, Emanuel ; Filice, Federica ; Schwaller, Beat

    In: Frontiers in Molecular Neuroscience, 2018, vol. 11, p. -

    Due to the complex and heterogeneous etiology of autism spectrum disorder (ASD), identification of convergent pathways and/or common molecular endpoints in the pathophysiological processes of ASD development are highly needed in order to facilitate treatment approaches targeted at the core symptoms. We recently reported on decreased expression of the Ca2+-binding protein parvalbumin (PV) in...

    Université de Fribourg

    17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms

    Filice, Federica ; Lauber, Emanuel ; Vörckel, Karl Jakob ; Wöhr, Markus ; Schwaller, Beat

    In: Molecular Autism, 2018, vol. 9, p. 15

    Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by two core symptoms: impaired social interaction and communication, and restricted, repetitive behaviors and interests. The pathophysiology of ASD is not yet fully understood, due to a plethora of genetic and environmental risk factors that might be associated with or causal for ASD. Recent findings...

    Université de Fribourg

    Parvalbumin neurons as a hub in autism spectrum disorders

    Lauber, Emanuel ; Filice, Federica ; Schwaller, Beat

    In: Journal of Neuroscience Research, 2018, vol. 96, no. 3, p. 360–361

    Université de Fribourg

    Prenatal valproate exposure differentially affects parvalbumin-expressing neurons and related circuits in the cortex and striatum of mice

    Lauber, Emanuel ; Filice, Federica ; Schwaller, Beat

    In: Frontiers in Molecular Neuroscience, 2016, vol. 9, p. -

    Autism spectrum disorders (ASD) comprise a number of heterogeneous neurodevelopmental diseases characterized by core behavioral symptoms in the domains of social interaction, language/communication and repetitive or stereotyped patterns of behavior. In utero exposure to valproic acid (VPA) has evolved as a highly recognized rodent ASD model due to the robust behavioral phenotype observed in...